Department of Pathology and Immunology, Washington University, St. Louis, MO, USA.
Int J Lab Hematol. 2020 Jun;42 Suppl 1:121-132. doi: 10.1111/ijlh.13210.
Neutropenia is a common laboratory finding in adults and children. Its underlying causes are extremely heterogeneous and include benign conditions, autoimmune disorders, infections, and malignancies. The clinical laboratory plays a central role in the diagnosis of these disorders, including data derived from hematology, microbiology, molecular biology/cytogenetics, and clinical chemistry. The purpose of this review is to (a) highlight the clinical, hematologic, and molecular genetic features of the major entities resulting in neutropenia and (b) outline an algorithm-based approach to permit the classification of neutropenias.
中性粒细胞减少症是成人和儿童中常见的实验室发现。其根本原因极其多样，包括良性疾病、自身免疫性疾病、感染和恶性肿瘤。临床实验室在这些疾病的诊断中起着核心作用，包括来自血液学、微生物学、分子生物学/细胞遗传学和临床化学的数据。本综述的目的是：(a) 强调导致中性粒细胞减少症的主要实体的临床、血液学和分子遗传学特征；(b) 概述一种基于算法的方法，以允许对中性粒细胞减少症进行分类。
