Gastroenterology, Hexian Memorial Affiliated Hospital of Southern Medical University, China.
Oncology, Hexian Memorial Affiliated Hospital of Southern Medical University, China.
Rev Esp Enferm Dig. 2020 Aug;112(8):620-626. doi: 10.17235/reed.2020.6699/2019.
dietary β-carotene and vitamin A intake have shown some potential effect in the development of esophageal cancer. This meta-analysis was performed to investigate the association of β-carotene and vitamin A intake on the risk of esophageal cancer.
the PubMed, Embase, Web of Science and Wanfang Med online databases were systematically searched to collect the relevant articles regarding the impact of β-carotene and vitamin A intake on esophageal cancer risk. Pooled odds ratios (OR) with 95 % confidence intervals (CI) were combined using the Review Manager Version 5.3 software.
this meta-analysis included 14 articles. The highest category of β-carotene intake may significantly reduce the risk of esophageal cancer compared with the lowest category (OR = 0.62, 95 % CI = 0.50-0.77). Similar significant results were found in American and European populations but not in other populations with β-carotene intake. An inverse association was found between vitamin A intake and esophageal cancer risk (OR = 0.79, 95 % CI = 0.63-0.99). No potential publication bias was detected.
our study suggested that dietary β-carotene and vitamin A intake may reduce the risk of esophageal cancer. More relevant studies are needed to further explore this association, as there were some limitations in our analysis.
饮食中β-胡萝卜素和维生素 A 的摄入与食管癌的发生有一定的相关性。本荟萃分析旨在研究β-胡萝卜素和维生素 A 摄入与食管癌风险之间的关系。
通过检索 PubMed、Embase、Web of Science 和万方医学在线数据库，收集关于β-胡萝卜素和维生素 A 摄入对食管癌风险影响的相关文章。采用 Review Manager Version 5.3 软件合并汇总比值比（OR）及其 95 %置信区间（CI）。
本荟萃分析共纳入 14 篇文章。与最低摄入量相比，β-胡萝卜素摄入量最高组食管癌发病风险显著降低（OR = 0.62，95 % CI = 0.50-0.77）。这种相关性在美国和欧洲人群中存在，但在其他人群中并不存在。维生素 A 摄入量与食管癌风险呈负相关（OR = 0.79，95 % CI = 0.63-0.99）。未发现潜在的发表偏倚。
本研究表明，饮食中β-胡萝卜素和维生素 A 的摄入可能降低食管癌的发病风险。由于我们的分析存在一些局限性，需要更多的相关研究来进一步探讨这种相关性。
