Mohajeri-Tehrani Mohammad Reza, Darvishian Najmeh, Arab Faezeh, Salemkar Sedigheh, Mohseni Fariba, Larijani Bagher, Hamidi Zohreh
Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Shariati Hospital, 5th floor, North Kargar Ave. P.C., Tehran, 14114-13137 Iran.
J Diabetes Metab Disord. 2019 Nov 14;19(1):431-435. doi: 10.1007/s40200-019-00455-6. eCollection 2020 Jun.
Prevalence of osteoporosis reported as high as 50% in thalassemia major patients. We compared bone density (BMD) of our patients with results of bone densitometry of participants of a national study, to find if BMD diagnosis is ethnicity sensitive or not.
In 177 adult beta thalassemia major patients and 490 normal subjects of 20-39 y/o range, dual-energy X-ray absorptiometry of the spine and femur performed. Normal subjects participated in Iranian Multi-center Osteoporosis Study (IMOS). Mean and standard deviation of normal ones achieved and Z-score of patients re-calculated based on normal Iranians. As BMD of normal participants and patients performed by devices of different brands, analyses done based on calculated standard BMD of all participants.
BMD of patients was significantly lower than normal participants ( value <0.001). Frequency of Z-score ≤-2 found in 52% and 56% of patients in femur and spine regions, respectively. New Z-score of patients according to Iranian normal populations calculated. Frequency of this new Z-score ≤-2 found in 16% and 72% of patients in femur and spine regions, respectively.
We think in secondary osteoporosis, may be other cut-off points, especially according to BMD of normal population of that geographical region are needed.
据报道，重型地中海贫血患者的骨质疏松患病率高达50%。我们将我们患者的骨密度（BMD）与一项全国性研究参与者的骨密度测量结果进行比较，以确定BMD诊断是否对种族敏感。
对177例成年重型β地中海贫血患者和490名年龄在20 - 39岁之间的正常受试者进行脊柱和股骨的双能X线吸收测定。正常受试者参与了伊朗多中心骨质疏松研究（IMOS）。得出正常受试者的均值和标准差，并根据伊朗正常人群重新计算患者的Z值。由于正常参与者和患者的BMD是由不同品牌的设备测量的，因此基于所有参与者计算出的标准BMD进行分析。
患者的BMD显著低于正常参与者（P值<0.001）。在股骨和脊柱区域，分别有52%和56%的患者Z值≤ -2。根据伊朗正常人群计算出患者的新Z值。在股骨和脊柱区域，分别有16%和72%的患者新Z值≤ -2。
我们认为在继发性骨质疏松中，可能需要其他截断点，特别是根据该地理区域正常人群的BMD来确定。
