Kelly Jennifer M, Matuszek Gregory, van den Broek Tim J, Huggins Gordon S, Smith Caren E, Ordovas Jose M, Wopereis Suzan, Booth Sarah L
Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.
Research Group Microbiology & Systems Biology, Netherlands Institute for Applied Science (TNO), Zeist, Netherlands.
Curr Dev Nutr. 2020 Jun 11;4(6):nzaa089. doi: 10.1093/cdn/nzaa089. eCollection 2020 Jun.
Inconsistent associations between lipids and circulating markers of fat-soluble vitamin and carotenoid status have been reported. The aim of this hypothesis-generating study was to examine the contribution of the LC-MS-based lipidome, characterized by lipid class, carbon count, and the number of unsaturated bonds, to the interindividual variability in circulating concentrations of retinol, carotenoids, 25-hydroxyvitamin D, α-tocopherol, γ-tocopherol, and phylloquinone in 35 overweight and obese, but healthy men. A sparse partial least-squares method was used to accomplish this aim. Highly abundant phospholipids and triglycerides (TGs) contributed to the interindividual variability in phylloquinone, α-tocopherol, and γ-tocopherol. Interindividual variability in lycopene concentrations was driven by concentrations of low-abundant TG. 25-Hydroxyvitamin D, retinol, and the other carotenoids were not influenced by lipids. Except for lycopene, evaluation of lipids beyond class does not appear to further explain the interindividual variability in circulating concentrations of fat-soluble vitamins and carotenoids.
已有报道称，脂质与脂溶性维生素及类胡萝卜素状态的循环标志物之间存在不一致的关联。这项产生假设的研究旨在探讨基于液相色谱-质谱联用技术的脂质组（以脂质类别、碳数和不饱和键数量为特征）对35名超重和肥胖但健康男性循环中视黄醇、类胡萝卜素、25-羟基维生素D、α-生育酚、γ-生育酚和叶绿醌浓度个体间差异的贡献。采用稀疏偏最小二乘法来实现这一目标。高度丰富的磷脂和甘油三酯（TGs）导致了叶绿醌、α-生育酚和γ-生育酚的个体间差异。番茄红素浓度的个体间差异由低丰度TG的浓度驱动。25-羟基维生素D、视黄醇和其他类胡萝卜素不受脂质影响。除番茄红素外，对脂质类别之外的脂质进行评估似乎并不能进一步解释脂溶性维生素和类胡萝卜素循环浓度的个体间差异。
