蛋白激酶G直系同源物EGL-4和PKG-2介导5-羟色胺诱导的……麻痹。（原文此处不完整） - Suppr

The protein kinase G orthologs, EGL-4 and PKG-2, mediate serotonin-induced paralysis of .

作者信息

Olson Andrew, Koelle Michael

机构信息

Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, SHM CE30, New Haven, CT 06520-8024.

出版信息

MicroPubl Biol. 2019 May 24;2019. doi: 10.17912/micropub.biology.000115.

DOI:10.17912/micropub.biology.000115

PMID:32550449

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7252333/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3ab/7252333/03c639cefe70/25789430-2019-micropub.biology.000115.jpg

相似文献

The protein kinase G orthologs, EGL-4 and PKG-2, mediate serotonin-induced paralysis of .蛋白激酶G直系同源物EGL-4和PKG-2介导5-羟色胺诱导的……麻痹。（原文此处不完整）

MicroPubl Biol. 2019 May 24;2019. doi: 10.17912/micropub.biology.000115.

egl-4 modulates electroconvulsive seizure duration in C. elegans.egl-4调节秀丽隐杆线虫的电惊厥发作持续时间。

Invert Neurosci. 2018 May 30;18(2):8. doi: 10.1007/s10158-018-0211-9.

Nuclear PKG localization is regulated by G₀ alpha and is necessary in the AWB neurons to mediate avoidance in Caenorhabditis elegans.核 PKG 的定位受 G₀ alpha 调控，在 AWB 神经元中是介导秀丽隐杆线虫逃避行为所必需的。

Neurosci Lett. 2013 Oct 11;553:35-9. doi: 10.1016/j.neulet.2013.08.011. Epub 2013 Aug 14.

A novel gain-of-function mutant of the cyclic GMP-dependent protein kinase egl-4 affects multiple physiological processes in Caenorhabditis elegans.一种新型的环鸟苷酸依赖性蛋白激酶egl-4功能获得性突变体影响秀丽隐杆线虫的多种生理过程。

Genetics. 2006 May;173(1):177-87. doi: 10.1534/genetics.106.057380. Epub 2006 Mar 17.

The Caenorhabditis elegans EGL-15 signaling pathway implicates a DOS-like multisubstrate adaptor protein in fibroblast growth factor signal transduction.秀丽隐杆线虫的EGL-15信号通路表明，在成纤维细胞生长因子信号转导中存在一种类似DOS的多底物衔接蛋白。

Mol Cell Biol. 2001 Dec;21(23):8104-16. doi: 10.1128/MCB.21.23.8104-8116.2001.

EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins.EGL-10在秀丽隐杆线虫神经系统中调节G蛋白信号传导，并与许多哺乳动物蛋白共享一个保守结构域。

Cell. 1996 Jan 12;84(1):115-25. doi: 10.1016/s0092-8674(00)80998-8.

EGL-3 and EGL-21 are required to trigger nocifensive response of Caenorhabditis elegans to noxious heat.EGL-3 和 EGL-21 需要触发秀丽隐杆线虫对有害热的伤害性反应。

Neuropeptides. 2019 Feb;73:41-48. doi: 10.1016/j.npep.2018.11.002. Epub 2018 Nov 13.

Transcription factor NFY globally represses the expression of the C. elegans Hox gene Abdominal-B homolog egl-5.转录因子NFY全面抑制秀丽隐杆线虫同源异形基因腹部B同源物egl-5的表达。

Dev Biol. 2007 Aug 15;308(2):583-92. doi: 10.1016/j.ydbio.2007.05.021. Epub 2007 May 25.

cGMP and a germ-line signal control body size in C. elegans through cGMP-dependent protein kinase EGL-4.环磷酸鸟苷（cGMP）和种系信号通过依赖于cGMP的蛋白激酶EGL-4调控秀丽隐杆线虫的体型大小。

Genes Cells. 2004 Sep;9(9):773-9. doi: 10.1111/j.1365-2443.2004.00771.x.

Sensitized genetic backgrounds reveal a role for C. elegans FGF EGL-17 as a repellent for migrating CAN neurons.敏感的遗传背景揭示了秀丽隐杆线虫成纤维细胞生长因子EGL-17作为迁移的CAN神经元的排斥因子的作用。

Development. 2005 Nov;132(21):4857-67. doi: 10.1242/dev.02020. Epub 2005 Oct 5.

引用本文的文献

Feedforward and feedback mechanisms cooperatively regulate rapid experience-dependent response adaptation in a single thermosensory neuron type.前馈和反馈机制协同调节单一热敏神经元类型中快速的经验依赖性反应适应。

Proc Natl Acad Sci U S A. 2024 Apr 2;121(14):e2321430121. doi: 10.1073/pnas.2321430121. Epub 2024 Mar 26.

Feedforward and feedback mechanisms cooperatively regulate rapid experience-dependent response adaptation in a single thermosensory neuron type.前馈和反馈机制协同调节单一热感觉神经元类型中快速的经验依赖性反应适应性。

bioRxiv. 2023 Dec 6:2023.12.05.570166. doi: 10.1101/2023.12.05.570166.

Regulation and modulation of biogenic amine neurotransmission in and .生物胺神经传递在……中的调节与调控

Front Physiol. 2023 Feb 16;14:970405. doi: 10.3389/fphys.2023.970405. eCollection 2023.

EGL-4 promotes turning behavior of males during mating.EGL-4促进雄性在交配过程中的转向行为。

MicroPubl Biol. 2021 Aug 18;2021. doi: 10.17912/micropub.biology.000433. eCollection 2021.

本文引用的文献

Serotonin and neuropeptides are both released by the HSN command neuron to initiate Caenorhabditis elegans egg laying.血清素和神经肽都是由 HSN 命令神经元释放的，以启动秀丽隐杆线虫的产卵。

PLoS Genet. 2019 Jan 24;15(1):e1007896. doi: 10.1371/journal.pgen.1007896. eCollection 2019 Jan.

Control of serotonin transporter phosphorylation by conformational state.通过构象状态对血清素转运体磷酸化的调控

Proc Natl Acad Sci U S A. 2016 May 17;113(20):E2776-83. doi: 10.1073/pnas.1603282113. Epub 2016 May 2.

Serotonin and the neuropeptide PDF initiate and extend opposing behavioral states in C. elegans.血清素和神经肽 PDF 在秀丽隐杆线虫中启动并延长对立的行为状态。

Cell. 2013 Aug 29;154(5):1023-1035. doi: 10.1016/j.cell.2013.08.001. Epub 2013 Aug 22.

Receptors and other signaling proteins required for serotonin control of locomotion in Caenorhabditis elegans.调控秀丽隐杆线虫运动的血清素受体及其他信号蛋白。

Genetics. 2012 Dec;192(4):1359-71. doi: 10.1534/genetics.112.142125. Epub 2012 Sep 28.

Cyclic GMP-dependent stimulation of serotonin transport does not involve direct transporter phosphorylation by cGMP-dependent protein kinase.环鸟苷酸依赖性刺激 5-羟色胺转运不涉及环鸟苷酸依赖性蛋白激酶对转运体的直接磷酸化。

J Biol Chem. 2012 Oct 19;287(43):36051-8. doi: 10.1074/jbc.M112.394726. Epub 2012 Aug 31.

Nuclear cGMP-dependent kinase regulates gene expression via activity-dependent recruitment of a conserved histone deacetylase complex.核 cGMP 依赖性激酶通过活性依赖性募集保守的组蛋白去乙酰化酶复合物来调节基因表达。

PLoS Genet. 2011 May;7(5):e1002065. doi: 10.1371/journal.pgen.1002065. Epub 2011 May 5.

Dual excitatory and inhibitory serotonergic inputs modulate egg laying in Caenorhabditis elegans.双重兴奋性和抑制性血清素能输入调节秀丽隐杆线虫的产卵行为。

Genetics. 2009 Jan;181(1):153-63. doi: 10.1534/genetics.108.096891. Epub 2008 Nov 10.

Phosphorylation of threonine residue 276 is required for acute regulation of serotonin transporter by cyclic GMP.环磷酸鸟苷（cGMP）对血清素转运体的急性调节需要苏氨酸残基276的磷酸化。

J Biol Chem. 2007 Apr 20;282(16):11639-47. doi: 10.1074/jbc.M611353200. Epub 2007 Feb 19.

A human serotonin transporter mutation causes constitutive activation of transport activity.一种人类血清素转运体突变导致转运活性的组成性激活。

Mol Pharmacol. 2003 Aug;64(2):440-6. doi: 10.1124/mol.64.2.440.

Regulation of body size and behavioral state of C. elegans by sensory perception and the EGL-4 cGMP-dependent protein kinase.通过感官感知和EGL-4环鸟苷酸依赖性蛋白激酶对秀丽隐杆线虫身体大小和行为状态的调节。

Neuron. 2002 Dec 19;36(6):1091-102. doi: 10.1016/s0896-6273(02)01093-0.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

The protein kinase G orthologs, EGL-4 and PKG-2, mediate serotonin-induced paralysis of .

作者信息

机构信息

出版信息

相似文献

引用本文的文献

本文引用的文献

文献检索

文件翻译

深度研究

Suppr 超能文献

相似文献

引用本文的文献

本文引用的文献