与果蝇elav不同，elav同源物并非在所有神经元中都有表达。 - Suppr

Suppr

超能文献

Unlike Drosophila elav, the elav orthologue is not panneuronally expressed.

作者信息

Pham Kenneth, Hobert Oliver

机构信息

Columbia University, Department of Biological Sciences, HHMI, New York, NY.

出版信息

MicroPubl Biol. 2019 Oct 30;2019. doi: 10.17912/micropub.biology.000189.

DOI:10.17912/micropub.biology.000189

PMID:32550450

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7252338/

Abstract

摘要

相似文献

Unlike Drosophila elav, the elav orthologue is not panneuronally expressed.与果蝇elav不同，elav同源物并非在所有神经元中都有表达。

MicroPubl Biol. 2019 Oct 30;2019. doi: 10.17912/micropub.biology.000189.

The role of the ELAV homologue EXC-7 in the development of the Caenorhabditis elegans excretory canals.ELAV同源物EXC-7在秀丽隐杆线虫排泄管发育中的作用。

Dev Biol. 2003 Apr 15;256(2):290-301. doi: 10.1016/s0012-1606(03)00040-x.

The commonly used marker ELAV is transiently expressed in neuroblasts and glial cells in the Drosophila embryonic CNS.常用标记物ELAV在果蝇胚胎中枢神经系统的神经母细胞和神经胶质细胞中短暂表达。

Dev Dyn. 2007 Dec;236(12):3562-8. doi: 10.1002/dvdy.21372.

Life-span phenotypes of elav and Rbp9 in Drosophila suggest functional cooperation of the two ELAV-family protein genes.果蝇 elav 和 Rbp9 的寿命表型表明这两个 ELAV 家族蛋白基因具有功能上的合作。

Arch Insect Biochem Physiol. 2010 Aug;74(4):261-5. doi: 10.1002/arch.20377.

Two neuronal, nuclear-localized RNA binding proteins involved in synaptic transmission.两种参与突触传递的神经元核定位RNA结合蛋白。

Curr Biol. 2003 Aug 5;13(15):1317-23. doi: 10.1016/s0960-9822(03)00532-3.

ELAV, a Drosophila neuron-specific protein, mediates the generation of an alternatively spliced neural protein isoform.ELAV是一种果蝇神经元特异性蛋白，介导一种选择性剪接的神经蛋白异构体的产生。

Curr Biol. 1996 Dec 1;6(12):1634-41. doi: 10.1016/s0960-9822(02)70787-2.

Neural specificity of elav expression: defining a Drosophila promoter for directing expression to the nervous system.elav 表达的神经特异性：定义一个用于将表达导向神经系统的果蝇启动子。

J Neurochem. 1994 Jul;63(1):41-51. doi: 10.1046/j.1471-4159.1994.63010041.x.

Subcellular distribution of Xenopus XEL-1 protein, a member of the neuron-specific ELAV/Hu family, revealed by epitope tagging.通过表位标签揭示的爪蟾XEL-1蛋白（神经元特异性ELAV/Hu家族成员）的亚细胞分布。

DNA Cell Biol. 1997 May;16(5):579-87. doi: 10.1089/dna.1997.16.579.

Characterization and spatial distribution of the ELAV protein during Drosophila melanogaster development.果蝇发育过程中ELAV蛋白的特征与空间分布

J Neurobiol. 1991 Jul;22(5):443-61. doi: 10.1002/neu.480220503.

found in neurons, a third member of the Drosophila elav gene family, encodes a neuronal protein and interacts with elav.在神经元中发现的果蝇elav基因家族的第三个成员，编码一种神经元蛋白并与elav相互作用。

Mech Dev. 2003 Mar;120(3):373-83. doi: 10.1016/s0925-4773(02)00444-6.

引用本文的文献

Antero-posterior patterning in the brittle star Amphipholis squamata and the evolution of echinoderm body plans.蛇尾纲动物鳞蛇尾的前后模式形成与棘皮动物身体结构的演化

Evodevo. 2025 May 31;16(1):7. doi: 10.1186/s13227-025-00244-8.

A pair of RNA binding proteins inhibit ion transporter expression to maintain lifespan.一对 RNA 结合蛋白抑制离子转运蛋白的表达以维持寿命。

Genetics. 2024 Feb 7;226(2). doi: 10.1093/genetics/iyad212.

Molecular characterization of nervous system organization in the hemichordate acorn worm Saccoglossus kowalevskii.棘皮动物半索动物门弓蛔虫神经系统组织的分子特征。

PLoS Biol. 2023 Sep 19;21(9):e3002242. doi: 10.1371/journal.pbio.3002242. eCollection 2023 Sep.

Transcriptional profiling from whole embryos to single neuroblast lineages in Drosophila.在果蝇中从整个胚胎到单个神经母细胞谱系的转录谱分析。

Dev Biol. 2022 Sep;489:21-33. doi: 10.1016/j.ydbio.2022.05.018. Epub 2022 Jun 1.

Spliceosomal component PRP-40 is a central regulator of microexon splicing.剪接体成分 PRP-40 是 microexon 剪接的核心调节剂。

Cell Rep. 2021 Aug 3;36(5):109464. doi: 10.1016/j.celrep.2021.109464.

A nervous system-specific subnuclear organelle in Caenorhabditis elegans.秀丽隐杆线虫中神经系统特异性亚核细胞器。

Genetics. 2021 Mar 3;217(1):1-17. doi: 10.1093/genetics/iyaa016.

本文引用的文献

Transcription factor autoregulation is required for acquisition and maintenance of neuronal identity.转录因子的自身调控对于神经元的身份获得和维持是必需的。

Development. 2019 Jun 21;146(13):dev177378. doi: 10.1242/dev.177378.

Robust Genome Editing with Short Single-Stranded and Long, Partially Single-Stranded DNA Donors in .利用短单链和长、部分单链 DNA 供体在. 中进行稳健的基因组编辑。

Genetics. 2018 Nov;210(3):781-787. doi: 10.1534/genetics.118.301532. Epub 2018 Sep 13.

Regulatory Logic of Pan-Neuronal Gene Expression in C. elegans.秀丽隐杆线虫中泛神经元基因表达的调控逻辑

Neuron. 2015 Aug 19;87(4):733-50. doi: 10.1016/j.neuron.2015.07.031.

A pair of RNA-binding proteins controls networks of splicing events contributing to specialization of neural cell types.一对RNA结合蛋白控制着有助于神经细胞类型特化的剪接事件网络。

Mol Cell. 2014 Jun 19;54(6):946-959. doi: 10.1016/j.molcel.2014.05.004. Epub 2014 Jun 5.

Rapid functional diversification in the structurally conserved ELAV family of neuronal RNA binding proteins.结构保守的神经元RNA结合蛋白ELAV家族中的快速功能多样化。

BMC Genomics. 2008 Aug 20;9:392. doi: 10.1186/1471-2164-9-392.

Dev Dyn. 2007 Dec;236(12):3562-8. doi: 10.1002/dvdy.21372.

Two neuronal, nuclear-localized RNA binding proteins involved in synaptic transmission.两种参与突触传递的神经元核定位RNA结合蛋白。

Curr Biol. 2003 Aug 5;13(15):1317-23. doi: 10.1016/s0960-9822(03)00532-3.

The role of the ELAV homologue EXC-7 in the development of the Caenorhabditis elegans excretory canals.ELAV同源物EXC-7在秀丽隐杆线虫排泄管发育中的作用。

Dev Biol. 2003 Apr 15;256(2):290-301. doi: 10.1016/s0012-1606(03)00040-x.

A conditional tissue-specific transgene expression system using inducible GAL4.一种使用可诱导型GAL4的条件性组织特异性转基因表达系统。

Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12596-601. doi: 10.1073/pnas.221303298.

Neuronal expression of a Caenorhabditis elegans elav-like gene and the effect of its ectopic expression.秀丽隐杆线虫elav样基因的神经元表达及其异位表达的影响。

Biochem Biophys Res Commun. 1999 Jul 14;260(3):646-52. doi: 10.1006/bbrc.1999.0957.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验