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使用解吸电喷雾电离质谱成像（DESI-MSI）技术分析腮腺大腺体中主要毒素的分布情况。

Distribution of major toxins in parotoid macroglands using Desorption-Electrospray-Ionization mass spectrometry imaging (DESI-MSI).

作者信息

Mailho-Fontana Pedro L, Porcari Andreia M, Eberlin Marcos N, Jared Carlos, Antoniazzi Marta Maria, Pimenta Daniel C, Sciani Juliana M

机构信息

Laboratório de Biologia Estrutural, Instituto Butantan, Av. Vital Brasil 1500, 05503-900, São Paulo, Brazil.

Universidade São Francisco, Av. São Francisco de Assis 218, 12916-900, Bragança Paulista, Brazil.

出版信息

Toxicon X. 2020 Apr 28;6:100033. doi: 10.1016/j.toxcx.2020.100033. eCollection 2020 Jun.

DOI:10.1016/j.toxcx.2020.100033
PMID:32550588
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7286094/
Abstract

Amphibian cutaneous glands secrete toxins used in different vital functions including passive defense. Through Desorption Electrospray Ionization-Imaging we analyzed the distribution of the major toxins of the toad parotoid macroglands. Alkaloids and steroids showed characteristic distribution and intensity within the glands and were also present at lower levels on the skin surface. A comprehensive overview of toxins distribution in toads' skin might help to understand their full biological role within the amphibians.

摘要

两栖动物的皮肤腺分泌用于不同重要功能（包括被动防御）的毒素。通过解吸电喷雾电离成像技术，我们分析了蟾蜍腮腺大腺体中主要毒素的分布情况。生物碱和类固醇在腺体内呈现出特征性的分布和强度，在皮肤表面也有较低水平的存在。全面了解蟾蜍皮肤中毒素的分布情况可能有助于理解它们在两栖动物体内的完整生物学作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b1b/7286094/84bcd6ca80a1/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b1b/7286094/6f387bf128bc/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b1b/7286094/864f04b934a3/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b1b/7286094/84bcd6ca80a1/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b1b/7286094/6f387bf128bc/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b1b/7286094/864f04b934a3/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b1b/7286094/84bcd6ca80a1/gr2.jpg

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本文引用的文献

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Sci Rep. 2019 Dec 6;9(1):18490. doi: 10.1038/s41598-019-54765-z.
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Biochemical and Biological Profile of Parotoid Secretion of the Amazonian (Anura: Bufonidae).亚马逊河蟾蜍（Anura: Bufonidae）腮腺分泌物的生化和生物学特征。
Biomed Res Int. 2019 Feb 21;2019:2492315. doi: 10.1155/2019/2492315. eCollection 2019.
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The Amphibian Diacylglycerol O-acyltransferase 2 (DGAT2): a 'paleo-protein' with Conserved Function but Unique Folding.
两栖动物二酰基甘油酰基转移酶 2（DGAT2）：具有保守功能但独特折叠的“古蛋白”。
Protein J. 2019 Feb;38(1):83-94. doi: 10.1007/s10930-019-09814-x.
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Comparative Analysis of Hydrophilic Ingredients in Toad Skin and Toad Venom Using the UHPLC-HR-MS/MS and UPLC-QqQ-MS/MS Methods Together with the Anti-Inflammatory Evaluation of Indolealkylamines.同时采用 UHPLC-HR-MS/MS 和 UPLC-QqQ-MS/MS 方法对蟾皮和蟾酥中亲水成分进行比较分析及吲哚烷胺类的抗炎评价
Molecules. 2018 Dec 27;24(1):86. doi: 10.3390/molecules24010086.
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