J Drugs Dermatol. 2020 Mar 1;19(3):295-304.
To assess differences in patient-reported treatment side effects and concerns associated with azelaic acid 15% foam (AAF) vs metronidazole cream (MC) and metronidazole gel (MG).
This study used matching-adjusted indirect comparison (MAIC) to compare patient-reported outcomes from survey data evaluating rosacea treatments. Outcomes of interest included percentages of patients reporting concerns and side effects and measures of importance of the concerns and tolerability of the side effects. Patients in each analysis (MG vs AAF and MC vs AAF) were matched using stabilized inverse propensity scores.
When compared to AAF, MG-treated patients more frequently reported concerns with treatment efficacy (54% vs 4%), application (7% vs 3%), and treatment side effects. MC-treated patients more frequently reported concerns with treatment efficacy (61% vs 5%) and dryness (8% vs 5%). AAF-treated patients more frequently reported concerns with cost of treatment compared with MG (7% vs 1%) and MC (9% vs 4%). Among patients reporting concerns, level of importance associated with these concerns was similar for AAF-treated patients compared with MG- and MC-treated patients. When compared to AAF-treated patients, MG-treated patients more frequently reported side effects of dryness (26% vs 15%) and uneven skin tone (3% vs 0%), and MC-treated patients more frequently reported side effects of burning (7% vs 3%), itching (7% vs 5%), and redness (7% vs 5%). MG- and MC-treated patients indicated greater intolerance for reported side effects than AAF-treated patients.
MG- and MC-treated patients more frequently reported treatment concerns and side effects than AAF-treated patients, and tolerability of those side effects was higher for patients treated with AAF. While treatment cost is a more frequent concern in patients treated with AAF, these patients less frequently reported concerns with treatment efficacy and reported similar or greater tolerance to side effects than patients treated with either MC or MG. J Drugs Dermatol. 2020;19(3): doi:10.36849/JDD.2020.3679.
评估与壬二酸 15%泡沫剂（AAF）相比，甲硝唑乳膏（MC）和甲硝唑凝胶（MG）治疗相关的患者报告的治疗副作用和担忧的差异。
本研究使用匹配调整间接比较（MAIC）比较了评估酒渣鼻治疗的调查数据中的患者报告结局。感兴趣的结局包括报告担忧和副作用的患者比例，以及对担忧的重要性和对副作用的耐受性的测量。在每个分析（MG 与 AAF 和 MC 与 AAF）中，使用稳定的逆倾向评分对患者进行匹配。
与 AAF 相比，MG 治疗的患者更频繁地报告治疗效果（54%对 4%）、应用（7%对 3%）和治疗副作用的担忧。MC 治疗的患者更频繁地报告治疗效果（61%对 5%）和干燥（8%对 5%）的担忧。与 MG（7%对 1%）和 MC（9%对 4%）相比，AAF 治疗的患者更频繁地报告治疗费用的担忧。在报告担忧的患者中，与 AAF 治疗的患者相比，MG 和 MC 治疗的患者对这些担忧的重视程度相似。与 AAF 治疗的患者相比，MG 治疗的患者更频繁地报告干燥（26%对 15%）和肤色不均（3%对 0%）的副作用，MC 治疗的患者更频繁地报告灼热（7%对 3%）、瘙痒（7%对 5%）和发红（7%对 5%）的副作用。MG 和 MC 治疗的患者对报告的副作用的耐受性低于 AAF 治疗的患者。
MG 和 MC 治疗的患者比 AAF 治疗的患者更频繁地报告治疗担忧和副作用，而 AAF 治疗的患者对这些副作用的耐受性更高。虽然 AAF 治疗的患者更频繁地关注治疗费用，但这些患者对治疗效果的担忧程度低于 MC 或 MG 治疗的患者，并且报告的副作用的耐受性相似或更高。J 皮肤病学杂志。2020;19(3):doi:10.36849/JDD.2020.3679.
