Caiado Helena, Conceição Natércia, Tiago Daniel, Marreiros Ana, Vicente Susana, Enriquez Jose Luis, Vaz Ana Margarida, Antunes Artur, Guerreiro Horácio, Caldeira Paulo, Cancela M Leonor
ProRegeM PhD Programme in Mechanisms of disease and regenerative medicine, University of Algarve, Faro, 8005-139, Portugal.
Center of Marine Sciences (CCMAR), University of Algarve, Faro, 8005-139, Portugal.
Data Brief. 2020 May 25;31:105765. doi: 10.1016/j.dib.2020.105765. eCollection 2020 Aug.
The data presented in this article is related with the research paper entitled "Evaluation of MGP gene expression in colorectal cancer", available on Gene journal [1]. From all the transcription factors known to regulate , FGF2 is the most described in colon adenocarcinoma and colon tumor cell lines, where it was shown to: i) contribute for the invasiveness potential; and ii) promote proliferation and survival of colorectal cancer cells. These studies pose the hypothesis that FGF2 associated signaling pathways could be promoting the regulation of others genes, such as that may lead to tumor progression which ultimately could result in poor prognosis in colon adenocarcinoma.
本文所呈现的数据与发表于《基因》杂志[1]上的题为《结直肠癌中MGP基因表达的评估》的研究论文相关。在所有已知可调节的转录因子中,FGF2在结肠腺癌和结肠肿瘤细胞系中被描述得最多,研究表明它:i)有助于侵袭潜能;ii)促进结肠癌细胞的增殖和存活。这些研究提出了一个假设,即FGF2相关信号通路可能促进其他基因的调控,例如可能导致肿瘤进展,最终可能导致结肠腺癌预后不良的基因。