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Use of Spironolactone in SARS-CoV-2 ARDS Patients.

作者信息

Dumanlı Güleren Yartaş, Dilken Olcay, Ürkmez Seval

机构信息

Department of Intensive Care, İstanbul University-Cerrahpaşa, Cerrahpaşa School of Medicine, İstanbul, Turkey.

出版信息

Turk J Anaesthesiol Reanim. 2020 Jun;48(3):254-255. doi: 10.5152/TJAR.2020.569. Epub 2020 Apr 30.

DOI:10.5152/TJAR.2020.569
PMID:32551456
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7279869/
Abstract
摘要

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Use of Spironolactone in SARS-CoV-2 ARDS Patients.螺内酯在新型冠状病毒肺炎急性呼吸窘迫综合征患者中的应用。
Turk J Anaesthesiol Reanim. 2020 Jun;48(3):254-255. doi: 10.5152/TJAR.2020.569. Epub 2020 Apr 30.
2
Spironolactone: An Anti-androgenic and Anti-hypertensive Drug That May Provide Protection Against the Novel Coronavirus (SARS-CoV-2) Induced Acute Respiratory Distress Syndrome (ARDS) in COVID-19.螺内酯：一种抗雄激素和抗高血压药物，可能对新型冠状病毒（SARS-CoV-2）引起的2019冠状病毒病急性呼吸窘迫综合征（ARDS）提供保护。
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Spironolactone: An Anti-androgenic and Anti-hypertensive Drug That May Provide Protection Against the Novel Coronavirus (SARS-CoV-2) Induced Acute Respiratory Distress Syndrome (ARDS) in COVID-19.螺内酯：一种抗雄激素和抗高血压药物，可能对新型冠状病毒（SARS-CoV-2）引起的2019冠状病毒病急性呼吸窘迫综合征（ARDS）提供保护。
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Spironolactone may provide protection from SARS-CoV-2: Targeting androgens, angiotensin converting enzyme 2 (ACE2), and renin-angiotensin-aldosterone system (RAAS).螺内酯可能提供针对 SARS-CoV-2 的保护：靶向雄激素、血管紧张素转换酶 2（ACE2）和肾素-血管紧张素-醛固酮系统（RAAS）。
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本文引用的文献

1
Can spironolactone be used to prevent COVID-19-induced acute respiratory distress syndrome in patients with hypertension?螺内酯能否用于预防高血压患者的新型冠状病毒肺炎诱导的急性呼吸窘迫综合征？
Am J Physiol Endocrinol Metab. 2020 May 1;318(5):E587-E588. doi: 10.1152/ajpendo.00136.2020.
2
COVID-19 pneumonia: different respiratory treatments for different phenotypes?新冠肺炎：针对不同表型采用不同的呼吸治疗方法？
Intensive Care Med. 2020 Jun;46(6):1099-1102. doi: 10.1007/s00134-020-06033-2. Epub 2020 Apr 14.
3
The effect of corticosteroid treatment on patients with coronavirus infection: a systematic review and meta-analysis.皮质类固醇治疗冠状病毒感染患者的效果：系统评价和荟萃分析。
J Infect. 2020 Jul;81(1):e13-e20. doi: 10.1016/j.jinf.2020.03.062. Epub 2020 Apr 10.
4
COVID-19 and the RAAS-a potential role for angiotensin II?新型冠状病毒肺炎与肾素-血管紧张素-醛固酮系统——血管紧张素II的潜在作用？
Crit Care. 2020 Apr 7;24(1):136. doi: 10.1186/s13054-020-02862-1.
5
Surviving Sepsis Campaign: guidelines on the management of critically ill adults with Coronavirus Disease 2019 (COVID-19).拯救脓毒症运动：2019 冠状病毒病（COVID-19）危重症成人管理指南。
Intensive Care Med. 2020 May;46(5):854-887. doi: 10.1007/s00134-020-06022-5. Epub 2020 Mar 28.
6
Delayed spironolactone administration prevents the transition from acute kidney injury to chronic kidney disease through improving renal inflammation.延迟螺内酯给药通过改善肾脏炎症来防止急性肾损伤向慢性肾脏病的转变。
Nephrol Dial Transplant. 2019 May 1;34(5):794-801. doi: 10.1093/ndt/gfy246.
7
Incident Hyperkalemia, Hypokalemia, and Clinical Outcomes During Spironolactone Treatment of Heart Failure With Preserved Ejection Fraction: Analysis of the TOPCAT Trial.螺内酯治疗射血分数保留的心力衰竭期间的事件性高钾血症、低钾血症和临床结局：TOPCAT 试验分析。
J Card Fail. 2018 May;24(5):313-320. doi: 10.1016/j.cardfail.2018.03.002. Epub 2018 Mar 20.
8
Efficacy and Safety of Spironolactone in Acute Heart Failure: The ATHENA-HF Randomized Clinical Trial.螺内酯治疗急性心力衰竭的疗效和安全性：ATHENA-HF 随机临床试验。
JAMA Cardiol. 2017 Sep 1;2(9):950-958. doi: 10.1001/jamacardio.2017.2198.
9
Clinical Experience With IV Angiotensin II Administration: A Systematic Review of Safety.静脉注射血管紧张素II的临床经验：安全性的系统评价
Crit Care Med. 2017 Aug;45(8):1285-1294. doi: 10.1097/CCM.0000000000002441.