Department of Orthopedics, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
J Int Med Res. 2020 Jun;48(6):300060520931612. doi: 10.1177/0300060520931612.
Aseptic loosening, the most frequent complication after total joint replacement, is probably caused by an inflammatory response to the shedding of wear debris from the implant. The only effective treatment is surgical revision. Using a mouse model, we investigated whether enalapril inhibits wear debris-induced inflammatory osteolysis.
Titanium (Ti) alloy particles were introduced, and calvarial bone from syngeneic mice was implanted into air pouches established in BALB/c mice. Histological and molecular analyses were performed with inflammatory tissue samples obtained from mice treated with and without enalapril.
Enalapril inhibited tissue inflammation and inflammatory osteolysis induced by Ti particles, reducing pouch membrane thickness and decreasing inflammatory cell infiltration. In addition, enalapril inhibited the expression of the inflammatory cytokines vascular endothelial growth factor and tumor necrosis factor-α.
Our study provides evidence that enalapril inhibits Ti particle-induced inflammatory osteolysis, and it may be a potentially useful treatment for aseptic loosening.
无菌性松动是全关节置换术后最常见的并发症，可能是由植入物磨损碎片脱落引起的炎症反应引起的。唯一有效的治疗方法是手术翻修。本研究通过小鼠模型，探讨依那普利是否能抑制磨损颗粒诱导的炎症性骨溶解。
将钛（Ti）合金颗粒引入，将同基因小鼠的颅骨骨植入 BALB/c 小鼠建立的气囊中。对用和未用依那普利治疗的小鼠的炎性组织样本进行组织学和分子分析。
依那普利抑制了 Ti 颗粒诱导的组织炎症和炎症性骨溶解，减少了气囊膜的厚度并减少了炎症细胞浸润。此外，依那普利抑制了炎症细胞因子血管内皮生长因子和肿瘤坏死因子-α的表达。
本研究提供了依那普利抑制 Ti 颗粒诱导的炎症性骨溶解的证据，它可能是治疗无菌性松动的一种潜在有效方法。
