Tecnologico de Monterrey, Escuela Medicina y Ciencias de la Salud, Grupo de Enfoque en Medicina Cardiovascular y Metabolómica, Monterrey, México.
Clínica de Obesidad, Departamento de Endocrinología Pediátrica, Hospital Materno Infantil de Alta Especialidad, Secretaría de Salud, Guadalupe, Nuevo León, México.
Metab Syndr Relat Disord. 2020 Sep;18(7):333-340. doi: 10.1089/met.2020.0046. Epub 2020 Jun 16.
The present study aimed to determine the association of the triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) index with IR in pediatric patients with overweight (OW) and OB, to assess the ability of the TG/HDL-C index to predict IR, and to estimate the prevalence of IR and metabolic syndrome (MetS). A cross-sectional study comprised 628 Mexican children (2-16 years old) from the OB clinic. IR was estimated using the HOMA-IR index (‡2.5). The modified Adult Treatment Panel III criteria were used to define MetS. Correlation analyses and a receiver operating characteristic (ROC) curve were used to assess the association of the TG/HDL-C index with IR and to establish the best cutoff for the TG/HDL-C index. About 79.3% of the children presented IR and 55.4% MetS. Common findings in patients with IR were acanthosis nigricans (94.8%) and a TG/HDL-C index ‡2.27 (70.5%). Considering all the patients with a high TG/HDL-C index, 78.4% presented MetS, and 88.0% IR. The area under the curve-ROC for the ability of the TG/HDL-C index to predict IR was 0.72 ( < 0.001), with a sensitivity of 70.5% and specificity of 63.1%. TG/HDL-C index is a feasible alternative to the HOMA-IR index to predict IR in Mexican children with OW or OB. It might be used to identify children with the greatest need for treatment interventions.
本研究旨在确定甘油三酯/高密度脂蛋白胆固醇（TG/HDL-C）指数与超重（OW）和肥胖（OB）儿科患者胰岛素抵抗（IR）的相关性，评估 TG/HDL-C 指数预测 IR 的能力，并估计 IR 和代谢综合征（MetS）的患病率。这是一项横断面研究，纳入了来自 OB 诊所的 628 名墨西哥儿童（2-16 岁）。使用 HOMA-IR 指数（‡2.5）估计 IR。采用改良的成人治疗小组 III 标准定义 MetS。相关性分析和受试者工作特征（ROC）曲线用于评估 TG/HDL-C 指数与 IR 的相关性，并确定 TG/HDL-C 指数的最佳截断值。大约 79.3%的儿童存在 IR，55.4%存在 MetS。IR 患者常见的表现有黑棘皮病（94.8%）和 TG/HDL-C 指数‡2.27（70.5%）。考虑所有 TG/HDL-C 指数较高的患者，78.4%存在 MetS，88.0%存在 IR。TG/HDL-C 指数预测 IR 的 ROC 曲线下面积为 0.72（ < 0.001），灵敏度为 70.5%，特异性为 63.1%。在墨西哥 OW 或 OB 儿童中，TG/HDL-C 指数是预测 IR 的一种可行的替代 HOMA-IR 指数。它可以用于识别最需要治疗干预的儿童。
