Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, Sendai, Japan.
New Industry Creation Hatchery Center, Tohoku University, Sendai, Japan.
Monoclon Antib Immunodiagn Immunother. 2020 Aug;39(4):123-128. doi: 10.1089/mab.2020.0009. Epub 2020 Jun 18.
Trastuzumab is a humanized antibody against human epidermal growth factor receptor 2 (HER2) that offers significant survival benefits to patients with HER2-overexpressing breast or gastric cancer. HER2 is also known to be overexpressed in colon cancers. In this study, a novel anti-HER2 monoclonal antibody (mAb), HMab-19 (IgG, κ) was characterized for its anticancer activity in colon cancers. HMab-19 showed both antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity activities against Caco-2, a colon cancer cell line. Furthermore, HMab-19 significantly reduced tumor development in a Caco-2 xenograft model. These results suggest that treatment with HMab-19 may be a useful therapy for patients with HER2-expressing colon cancers.
曲妥珠单抗是一种针对人表皮生长因子受体 2（HER2）的人源化抗体，为 HER2 过表达的乳腺癌或胃癌患者提供了显著的生存获益。HER2 也被发现在结肠癌中过表达。在这项研究中，一种新型的抗 HER2 单克隆抗体（mAb）HMab-19（IgG，κ）因其在结肠癌中的抗癌活性而被表征。HMab-19 对结肠癌细胞系 Caco-2 表现出抗体依赖性细胞毒性和补体依赖性细胞毒性活性。此外，HMab-19 显著减少了 Caco-2 异种移植模型中的肿瘤发展。这些结果表明，用 HMab-19 治疗可能是治疗 HER2 表达的结肠癌患者的一种有效方法。
