Department of Endocrinology and Metabolism, Second People's Hospital of Chengdu, Chengdu 610017, Sichuan, China.
School of Health Policy and Management, Nanjing Medical University, Nanjing 211166, Jiangsu, China;Institute of Healthy Jiangsu Development, Nanjing Medical University, Nanjing 211166, Jiangsu, China;Center for Global Health, Nanjing Medical University, Nanjing 211166, Jiangsu, China.
Biomed Environ Sci. 2020 May 20;33(5):315-322. doi: 10.3967/bes2020.043.
This paper aimed to investigate the prevalence of diabetes mellitus (DM) and explore the associated risk factors in a very elderly southwest Chinese population.
From September 2015 to June 2016, a cross-sectional survey was conducted to obtain a representative sample of 1,326 participants over 80 years old living in Chengdu. The presence of DM was based on fasting plasma glucose (FPG) and 2-h plasma glucose (2-hPG) levels during an oral glucose tolerance test (OGTT). A logistic regression model was used to calculate the odds ratios ( s) and 95% confidence intervals ( s) of the potential associated factors.
The participants' mean age was 83.5 ± 3.1 years. The overall prevalence of DM was 27.4%. The prevalence was higher in males (30.2%) than females (24.7%) ( = 0.02). The prevalence of DM increased with body mass index (BMI) and decreased with aging. The multivariate analysis suggested that male sex ( = 1.433; 95% , 1.116-1.843), hypertension ( = 1.439; 95% , 1.079-1.936), overweight or obesity ( = 1.371; 95% , 1.023-1.834), high heart rate (≥ 75 beats/min; = 1.362; 95% , 1.063-1.746), and abdominal obesity ( = 1.615; 95% , 1.216-2.149) were all significantly positively correlated with DM. However, age was negatively correlated with DM ( = 0.952; 95% , 0.916-0.989).
The prevalence of DM and newly diagnosed DM in a very elderly southwest Chinese population was high. OGTT screening should be performed regularly in people aged ≥ 80 years to ensure timely diagnosis of DM.
本研究旨在调查中国西南部非常高龄人群中糖尿病（DM）的患病率，并探讨其相关危险因素。
2015 年 9 月至 2016 年 6 月，通过横断面调查，抽取了居住在成都的 1326 名 80 岁以上的老年人作为研究对象。DM 的诊断基于口服葡萄糖耐量试验（OGTT）中空腹血糖（FPG）和 2 小时血糖（2-hPG）水平。采用 logistic 回归模型计算潜在相关因素的比值比（OR）及其 95%置信区间（95%CI）。
参与者的平均年龄为 83.5 ± 3.1 岁。总体 DM 患病率为 27.4%。男性（30.2%）高于女性（24.7%）（ = 0.02）。DM 患病率随体重指数（BMI）的增加而升高，随年龄的增加而降低。多因素分析表明，男性（OR = 1.433；95%CI：1.116-1.843）、高血压（OR = 1.439；95%CI：1.079-1.936）、超重或肥胖（OR = 1.371；95%CI：1.023-1.834）、高心率（≥75 次/分；OR = 1.362；95%CI：1.063-1.746）和腹型肥胖（OR = 1.615；95%CI：1.216-2.149）与 DM 显著正相关，而年龄与 DM 呈负相关（OR = 0.952；95%CI：0.916-0.989）。
中国西南部非常高龄人群中 DM 患病率和新诊断 DM 患病率较高。≥80 岁人群应定期进行 OGTT 筛查，以确保及时诊断 DM。
