QSAR studies of hydrazone uncouplers of oxidative phosphorylation.
作者信息
Winkler D A, Holan G, Smith D R, Middleton E J, Hart N K, Rihs K, Smith K W
机构信息
CSIRO Division of Chemicals and Polymers, Melbourne, Australia.
出版信息
Drug Des Deliv. 1988 Jul;3(2):191-207.
PMID:3255329
Abstract
Semiempirical molecular orbital calculations have been performed on a series of hydrazone uncouplers of mitochondrial oxidative phosphorylation which show insecticidal activity. Regression analysis yielded significant correlations between uncoupling activity, insecticidal potency and such physicochemical or theoretically-derived parameters as lipophilicity, pKa and atom charges.
摘要
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