Antes PG, Rotterdam, The Netherlands.
Antes PG, Rotterdam, The Netherlands.
J Affect Disord. 2020 Jul 1;272:340-347. doi: 10.1016/j.jad.2020.03.181. Epub 2020 May 4.
Most studies regarding cognitive side-effects following ECT for treating depression report transient forms of cognitive disturbances. However, a growing number of studies also report considerable differences among individual patients.
The aim of this systematic review was to identify pretreatment patient characteristics for predicting the risk of developing cognitive side-effects following ECT.
Online databases PubMed/Medline, Embase, and PsycINFO were searched for articles published from 2002 through May 2019, using the following relevant search terms: #cognitive deficits AND #Electro Convulsive Therapy. Inclusion and exclusion criteria were applied for full-text inclusion. PRISMA guidelines were used.
Our initial search yielded 2155 publications; 16 studies were included. A total of 16 possible predictive factors were identified. Two factors, psychotic features and white matter hyperintensities, were conclusively found to not predict cognitive side-effects following ECT; the remaining 14 factors were inconclusive.
There is robust evidence that psychotic features and white matter hyperintensities are not predictive of cognitive side-effects following ECT. None of the other 14 factors examined were predictive, however these levels of evidence were weak and therefore inconclusive. Additional studies focusing primarily on pretreatment patient characteristics for predicting cognitive side-effects following ECT are needed, including demographic, clinical, physiological, neurobiological, and genetic factors. Finally, we provide suggestions for future research.
大多数关于电休克治疗（ECT）治疗抑郁症后认知副作用的研究报告了短暂形式的认知障碍。然而，越来越多的研究也报告了个体患者之间的显著差异。
本系统评价旨在确定预测 ECT 后发生认知副作用风险的治疗前患者特征。
使用以下相关搜索词，在线搜索了从 2002 年到 2019 年 5 月发表的文章：#认知缺陷和#电惊厥疗法。应用纳入和排除标准进行全文纳入。采用 PRISMA 指南。
我们最初的搜索产生了 2155 篇出版物；纳入了 16 项研究。共确定了 16 个可能的预测因素。有两个因素，即精神病特征和脑白质高信号，被明确发现不能预测 ECT 后的认知副作用；其余 14 个因素尚无定论。
有强有力的证据表明，精神病特征和脑白质高信号不能预测 ECT 后的认知副作用。然而，研究并未发现其他 14 个因素具有预测性，这些证据水平较弱，因此无定论。需要开展更多研究，主要关注治疗前患者特征，以预测 ECT 后的认知副作用，包括人口统计学、临床、生理、神经生物学和遗传因素。最后，我们提出了未来研究的建议。
