用于 SARS-CoV-2 研究的体外和动物模型。
In Vitro and Animal Models for SARS-CoV-2 research.
机构信息
Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan.
出版信息
Trends Pharmacol Sci. 2020 Aug;41(8):513-517. doi: 10.1016/j.tips.2020.05.005. Epub 2020 May 30.
Abstract
Basic research on SARS-CoV-2 is essential to understand its detailed pathophysiology and identify best drug targets. Models that can faithfully reproduce the viral life cycle and reproduce the pathology of COVID-19 are required. Here, we briefly review the cell lines, organoids, and animal models that are currently being used in COVID-19 research.
摘要
对 SARS-CoV-2 的基础研究对于了解其详细的病理生理学和确定最佳药物靶点至关重要。需要能够忠实地再现病毒生命周期并再现 COVID-19 病理学的模型。在这里，我们简要回顾一下目前用于 COVID-19 研究的细胞系、类器官和动物模型。
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