Corporal Michael J. Crescenz Veterans Affairs Medical Center and the Department of Dermatology, University of Pennsylvania.
Corporal Michael J. Crescenz Veterans Affairs Medical Center and the Department of Dermatology, University of Pennsylvania.
J Am Acad Dermatol. 2021 Apr;84(4):1051-1058. doi: 10.1016/j.jaad.2020.06.037. Epub 2020 Jun 15.
The use of herbal supplements that promise to improve immune health has gained popularity among dermatology patients. However, there is little to no evidence that herbal supplements improve dermatologic conditions. Several in vitro and in vivo studies have shown that Spirulina platensis, Aphanizomenon flos-aqua, Chlorella, Echinacea, and alfalfa activate immune cells via certain cytokines and chemokines. Case reports suggest the association of ingesting immunostimulatory herbs and the clinical onset or flares of diseases characterized by an exaggerated immune response such as lupus erythematosus, dermatomyositis, and autoimmune blistering disorders. Therefore, it is imperative to investigate the prevalence of herbal supplement use in this patient population. In addition, in vitro studies should examine the underlying mechanisms by which herbs stimulate immune pathways that are already overactive in autoimmune patients.
某些声称可以改善免疫健康的草药补充剂在皮肤科患者中越来越受欢迎。然而，几乎没有证据表明草药补充剂可以改善皮肤科疾病。一些体外和体内研究表明，螺旋藻、水华鱼腥藻、小球藻、紫锥菊和苜蓿通过某些细胞因子和趋化因子激活免疫细胞。病例报告表明，摄入免疫刺激草药与某些疾病的临床发作或恶化有关，这些疾病的特征是免疫反应过度，如红斑狼疮、皮肌炎和自身免疫性水疱病。因此，有必要调查此类患者群体中使用草药补充剂的流行情况。此外，体外研究应研究草药刺激已经在自身免疫患者中过度活跃的免疫途径的潜在机制。
