Pharmacy Department, Rotunda Hospital, Dublin 1, Ireland; Division of Population Health Sciences, Royal College of Surgeons in Ireland, Dublin 2, Ireland; Department of Haematology, Mater University Hospital, Dublin 7, Ireland.
Department of Paediatrics, Children's Health Ireland at Tallaght, Dublin 24, Ireland; SPHERE research group, Conway Institute, University College Dublin, Dublin 4, Ireland; Department of Haematology, Mater University Hospital, Dublin 7, Ireland.
Transl Res. 2020 Nov;225:20-32. doi: 10.1016/j.trsl.2020.06.004. Epub 2020 Jun 15.
Pregnancy associated venous thromboembolism (PA-VTE) is a leading cause of maternal morbidity and mortality worldwide. Despite the availability of international guidance on the prevention, diagnosis and treatment, practice differs between countries and clinical institutions. The evidence base in this area is limited due to the vulnerable population who are affected, with the majority of guidelines deriving their recommendations from experience in surgical and medical venous thromboembolic disease. This review includes best evidence in PA-VTE management, highlighting specific literature which supports current diagnosis, prevention, and treatment strategies. Additionally, we hope to demonstrate emerging trends in the field through discussion of ongoing trials designed to progress towards evidence-based practice in the context of PA-VTE.
妊娠相关静脉血栓栓塞症（PA-VTE）是全球孕产妇发病率和死亡率的主要原因。尽管有关于预防、诊断和治疗的国际指南，但各国和临床机构的实践存在差异。由于受影响的人群较为脆弱，该领域的证据基础有限，大多数指南的建议都是基于手术和医学静脉血栓栓塞性疾病的经验。本综述包括 PA-VTE 管理的最佳证据，重点介绍了支持当前诊断、预防和治疗策略的具体文献。此外，我们还希望通过讨论旨在朝着 PA-VTE 背景下循证实践发展的正在进行的试验，展示该领域的新趋势。
