University of Montreal Hospital Center, Montreal, Quebec, Canada.
Epileptic Disord. 2020 Jun 1;22(3):349-352. doi: 10.1684/epd.2020.1171.
Porphyrias are rare genetic disorders which cause a deficiency in the enzymes involved in the biosynthesis of heme. The treatment of epilepsy in patients with acute intermittent porphyria can be difficult since many anticonvulsants can increase heme synthesis and trigger porphyric attacks. We report a patient with focal epilepsy successfully treated with eslicarbazepine without exacerbation of porphyria.
卟啉症是一种罕见的遗传性疾病，会导致参与血红素生物合成的酶缺乏。急性间歇性卟啉症患者的癫痫治疗可能很困难，因为许多抗癫痫药会增加血红素合成并引发卟啉症发作。我们报告了一例局灶性癫痫患者，使用依沙佐双酮成功治疗，且卟啉症未恶化。
