Max Smart Hospital, Saket, New Delhi, India.
Max Hospital, Patparganj, New Delhi, India.
Indian J Pediatr. 2020 Dec;87(12):1040-1046. doi: 10.1007/s12098-020-03279-y. Epub 2020 Jun 18.
Infantile spasms, though long recognised, are still a cause of significant morbidity in children. The knowledge of their etiology and pathogenesis is still evolving. Even the management strategies vary among different centres. Hormonal treatments and vigabatrin have been recognised as effective but controversies prevail on the exact protocols that best balance the risk benefit ratio. Collaborative studies have begun to provide some clarity on some of the management issues but further large scale studies that further standardise protocols are a felt need. This article attempts to provide a clinically relevant summary of the current knowledge.
婴儿痉挛症虽然很早就被认识，但仍然是儿童发病和致残的重要原因。其病因和发病机制的认识仍在不断发展。即使是不同中心之间的治疗策略也存在差异。激素治疗和氨己烯酸已被认为是有效的，但在最佳平衡风险效益比的具体方案上仍存在争议。协作研究开始为一些管理问题提供了一些明确的信息，但需要进一步进行大规模的研究，进一步规范方案。本文试图对目前的知识进行临床相关的总结。
