硼苯丙氨酸在不同类型皮肤黑色素瘤中的生物分布研究。

Biodistribution studies of boronophenylalanine in different types of skin melanoma.

机构信息

Beijing Nuclear Industry Hospital(BNIH), China; Beijing Capture Technology Co. Ltd (BCTC), China.

The Third Xiangya Hospital of Central South University (The Third Xiangya Hospital), China.

出版信息

Appl Radiat Isot. 2020 Sep;163:109215. doi: 10.1016/j.apradiso.2020.109215. Epub 2020 May 11.

DOI:10.1016/j.apradiso.2020.109215

PMID:32561053

Abstract

A study of the B-enriched Boronophenylalanine-fructose complex(BPA-F) infusion procedure in potential BNCT patients, including three skin melanomas of extremities, was performed. B concentration in tumor(T), blood(B), skin(S) were measured to determine tumor/blood(T/B) and skin/blood(S/B) ratios. T/B ratio for three melanoma patients was in the range 1.48-3.82(average 2.56 ± 0.69). S/B ratio was in the range 0.81-1.99(average 1.29 ± 0.35). Results showed that T/B ratio of nodular metastasis melanoma was higher than superficial spreading melanoma. B concentration in skin was higher than blood, which was helpful to avoid over-dose in normal skin.

摘要

对包括 3 例肢体皮肤黑色素瘤在内的潜在 BNCT 患者进行了硼苯丙氨酸-果糖复合物（BPA-F）输注程序的研究。测量了肿瘤（T）、血液（B）和皮肤（S）中的硼浓度，以确定肿瘤/血液（T/B）和皮肤/血液（S/B）比值。3 例黑色素瘤患者的 T/B 比值在 1.48-3.82 之间（平均值 2.56 ± 0.69）。S/B 比值在 0.81-1.99 之间（平均值 1.29 ± 0.35）。结果表明，结节转移型黑色素瘤的 T/B 比值高于浅表扩散型黑色素瘤。皮肤中的硼浓度高于血液，这有助于避免正常皮肤的过量剂量。