Department of Cardiothoracic and Vascular Surgery, McGovern Medical School at The University of Texas Health Science Center at Houston and Memorial Hermann Hospital, Houston, Texas.
Department of Surgery, McGovern Medical School at The University of Texas Health Science Center at Houston and Memorial Hermann Hospital, Houston, Texas.
Ann Thorac Surg. 2020 Dec;110(6):1847-1853. doi: 10.1016/j.athoracsur.2020.04.125. Epub 2020 Jun 17.
This study evaluated the feasibility and durability of the modified Cabrol coronary reattachment technique after aortic root replacement.
The study retrospectively reviewed 370 patients who underwent aortic root replacement, during 1991 and 2018, and who were separated into 2 groups: a modified Carol (mCabrol) group (n = 84), consisting of patients with 1 or both coronary ostia reimplanted using a modified Cabrol technique; and a Carrel group (n = 286), consisting of patients with both coronary ostia reimplanted using the Carrel button technique.
Baseline characteristics were similar in the 2 groups, except the mCabrol group had higher rates of redo sternotomy (74% vs 16%), chronic aortic dissection (58% vs 19%), and infection (14% vs 3%). In the mCabrol group, 60% had both coronary arteries reattached with the technique, and 40% of the procedures were unilateral. Operative mortality was significantly higher in mCabrol group compared with the Carrel group. However, in the stratified analysis for resternotomy, operative mortality between 2 groups were similar (16% vs 13%; P = .786). The survival rate at 5 years and 10 years was 68 ± 6% and 44 ± 6%, respectively, in the mCabrol group and 87 ± 2% and 80 ± 3%, respectively, in the Carrel group (log-rank P < .001). After propensity adjustment, chronic kidney disease and prior coronary artery bypass grafting, but not the modified Cabrol technique, were independent predictors of both operative mortality and follow-up mortality (operative, P = .518; follow-up, P = .080). A total of 47 (66%) of 71 discharged patients in the mCabrol group had follow-up imaging, and no Cabrol graft was occluded. Two patients in the mCabrol group required interventions related to the reattachment technique: 1 coronary ostial anastomosis stenosis and 1 graft-to-graft anastomosis pseudoaneurysm.
The modified Cabrol reattachment technique was not predictive of increased mortality and has excellent patency.
本研究评估了改良 Cabrol 冠状动脉再附着技术在主动脉根部置换术后的可行性和耐久性。
研究回顾性分析了 1991 年至 2018 年期间接受主动脉根部置换术的 370 例患者,将其分为 2 组:改良 Carol(mCabrol)组(n=84),包括使用改良 Cabrol 技术重新植入 1 个或 2 个冠状动脉口的患者;Carrel 组(n=286),包括使用 Carrel 纽扣技术重新植入 2 个冠状动脉口的患者。
2 组患者的基线特征相似,除 mCabrol 组再开胸率(74% vs 16%)、慢性主动脉夹层(58% vs 19%)和感染(14% vs 3%)较高外。在 mCabrol 组中,60%的患者采用该技术同时附着 2 条冠状动脉,40%的患者采用单侧技术。mCabrol 组的手术死亡率明显高于 Carrel 组。然而,在再开胸的分层分析中,2 组间的手术死亡率相似(16% vs 13%;P=.786)。mCabrol 组 5 年和 10 年的生存率分别为 68±6%和 44±6%,Carrel 组分别为 87±2%和 80±3%(对数秩 P<.001)。在倾向评分调整后,慢性肾脏病和既往冠状动脉旁路移植术,但不是改良 Cabrol 技术,是手术死亡率和随访死亡率的独立预测因素(手术,P=.518;随访,P=.080)。mCabrol 组 71 例出院患者中,有 47 例(66%)进行了随访影像学检查,没有 Cabrol 移植物闭塞。mCabrol 组中有 2 例患者需要进行与再附着技术相关的干预:1 例冠状动脉口吻合口狭窄,1 例移植物-移植物吻合口假性动脉瘤。
改良 Cabrol 再附着技术并不增加死亡率,且通畅性良好。