Ohio State University, Nisonger Center Clinical Trials Program, Columbus.
J Am Acad Child Adolesc Psychiatry. 2021 Jan;60(1):26-28. doi: 10.1016/j.jaac.2020.06.002. Epub 2020 Jun 16.
In this issue of the Journal, Sucksdorff et al. present additional evidence of maternal health and nutrition during pregnancy affecting offspring mental health. In the Finnish National Registry, the authors identified 1,067 cases of attention-deficit/hyperactivity disorder (ADHD) and 1,067 matched controls. They found a highly significant negative association between maternal 25-hydroxyvitamin D levels in the first half of pregnancy and later diagnoses of ADHD in offspring. The lower the level of vitamin D in mothers, the greater the risk of ADHD in offspring, even after adjusting for maternal age and socioeconomic status (p = .002). This finding confirms what had previously been reported less conclusively and raises several points worthy of comment. Among these are the special characteristics of vitamin D within an array of micronutrients necessary for brain health, development, and function; the possibility that vitamin D levels are markers for general micronutrient insufficiency; the importance of nutrition for maternal mental health in view of the psychological impact of maternal mental state on the child; and the need for further research on brain nutrition, including randomized clinical trials (RCTs).
在本期杂志中，Sucksdorff 等人提出了更多证据表明孕期的母婴健康和营养状况会影响后代的心理健康。作者在芬兰国家登记处中，鉴定了 1067 例注意缺陷多动障碍（ADHD）和 1067 例匹配对照。他们发现，妊娠前半程母体 25-羟维生素 D 水平与后代 ADHD 诊断之间存在显著负相关。母亲体内维生素 D 水平越低，后代患 ADHD 的风险就越高，即使在调整了母亲年龄和社会经济地位后也是如此（p=0.002）。这一发现证实了之前报道的结果，并且提出了一些值得评论的观点。其中包括维生素 D 在一系列对大脑健康、发育和功能至关重要的微量营养素中的特殊作用；维生素 D 水平可能是一般微量营养素不足的标志物；鉴于母体精神状态对儿童的心理影响，营养对母婴心理健康的重要性；以及对脑营养进行进一步研究的必要性，包括随机临床试验（RCT）。
