Department of Children's Health Care, Guangdong Women and Children Hospital, Guangzhou Medical University, Guangzhou, 511400, China.
Biol Trace Elem Res. 2021 Apr;199(4):1253-1258. doi: 10.1007/s12011-020-02253-1. Epub 2020 Jun 19.
There are limited data regarding low lead exposure and iron status in Chinese children. This study aimed to examine the association between low-level lead exposure and iron status in a large population of children aged 0-5 years. We reviewed the records of children aged 0-5 years who had blood lead, iron, ferritin, and hemoglobin measurements during 2014-2017 at the Guangdong Women and Children Hospital. We identified 17,486 children with a blood lead level < 100 μg/L. Multiple linear and logistic regression analyses were performed to estimate the associations between blood lead levels and blood iron, serum ferritin, and hemoglobin. The mean concentrations of blood lead, iron, ferritin, and hemoglobin were 31.50 μg/L, 7.50 mmol/L, 46.98 ng/mL, and 120.41 g/L, respectively. Adjusting for age and sex, blood lead was negatively correlated with iron (r = - 0.073, p < 0.05), ferritin (r = - 0.043, p < 0.05), and hemoglobin (r = - 0.047, p < 0.05). Compared with the 1st quintile of lead exposure, the 5th quintile of lead exposure was associated with a 0.146 mmol/L decrease in blood iron, a 4.678 ng/mL decrease in serum ferritin, and a 1.245 g/L decrease in hemoglobin. Adjusted odds ratios (95% confidence interval) for the 5th quintile of blood lead were 1.39 (1.25-1.55) for iron deficiency and 1.45 (1.26-1.67) for anemia, relative to the 1st quintile. Our study findings confirmed the previously established association of blood lead levels with decreasing iron status and extended previous findings to even low-level lead exposure in Chinese children.
关于中国儿童低水平铅暴露和铁状态的相关数据有限。本研究旨在调查大量 0-5 岁儿童中低水平铅暴露与铁状态之间的关系。我们回顾了 2014-2017 年在广东省妇女儿童医院进行血液铅、铁、铁蛋白和血红蛋白检测的 0-5 岁儿童的记录。我们确定了 17486 名血铅水平<100μg/L 的儿童。采用多元线性和逻辑回归分析来估计血铅水平与血铁、血清铁蛋白和血红蛋白之间的关系。血铅、铁、铁蛋白和血红蛋白的平均浓度分别为 31.50μg/L、7.50mmol/L、46.98ng/mL 和 120.41g/L。在调整年龄和性别后，血铅与铁（r=-0.073，p<0.05）、铁蛋白（r=-0.043，p<0.05）和血红蛋白（r=-0.047，p<0.05）呈负相关。与第 1 五分位组相比，第 5 五分位组的血铁水平下降 0.146mmol/L，血清铁蛋白下降 4.678ng/mL，血红蛋白下降 1.245g/L。与第 1 五分位组相比，血铅第 5 五分位组铁缺乏的调整比值比（95%置信区间）为 1.39（1.25-1.55），贫血的调整比值比（95%置信区间）为 1.45（1.26-1.67）。我们的研究结果证实了先前建立的血铅水平与铁状态下降之间的关系，并将先前的发现扩展到中国儿童的低水平铅暴露。
