Department of Urology, The Second Hospital of Tianjin Medical University, Tianjin, China.
Cancer Med. 2020 Aug;9(15):5672-5677. doi: 10.1002/cam4.3086. Epub 2020 Jun 20.
To investigate the effect of serum aspartate transaminase/alanine transaminase (AST/ALT) on the risk of prostate cancer.
A total of 404 patients undergoing prostate biopsy from April 2016 to July 2019 were enrolled. One hundred and ninety-four patients with prostatic cancer (PCa) were diagnosed by pathology. Two hundred and ten patients were diagnosed with benign prostatic hyperplasia (BPH). Multivariate logistic regression was used to analyze the effect of AST/ALT ratio and other factors on the incidence of PCa.
AST/ALT ratio was significantly higher in PCa than in BPH patients (OR 2.313, 95%CI 1.337-4.003, P = .002). ROC curve indicated that the best cutoff was 1.155 in predicting the incidence risk of PCa. The age of PCa patients is higher than BPH patients (OR 1.054, 95%CI 1.027-1.082, P < .001). We also found that platelets were lower in PCa than in BPH patients. Multivariate analysis showed that AST/ALT ratio could be used as an independent predictor to assess the incident risk of PCa(OR 1.043, 95%CI 1.014-1.072, P = .003). However, AST/ALT ratio did not predict the incidence in high-risk or low-risk PCa.
AST/ALT ratio was an independent factor in predicting the incidence of PCa. When the level of AST/ALT ratio in serum raised, the incidence risk of PCa was significantly increased, which was helpful for the clinical diagnosis of PCa. We still needed a multicenter study to verify the role of AST/ALT ratio in the development of PCa.
研究血清天门冬氨酸氨基转移酶/丙氨酸氨基转移酶（AST/ALT）比值对前列腺癌（PCa）风险的影响。
共纳入 2016 年 4 月至 2019 年 7 月期间行前列腺穿刺活检的 404 例患者。其中 194 例患者经病理诊断为前列腺癌（PCa），210 例患者诊断为良性前列腺增生（BPH）。采用多因素 logistic 回归分析 AST/ALT 比值与其他因素对 PCa 发生率的影响。
PCa 患者 AST/ALT 比值明显高于 BPH 患者（OR 2.313，95%CI 1.337-4.003，P=0.002）。ROC 曲线表明，预测 PCa 发病风险的最佳截断值为 1.155。PCa 患者的年龄高于 BPH 患者（OR 1.054，95%CI 1.027-1.082，P<0.001）。我们还发现 PCa 患者的血小板计数低于 BPH 患者。多因素分析表明，AST/ALT 比值可作为评估 PCa 发病风险的独立预测指标（OR 1.043，95%CI 1.014-1.072，P=0.003）。然而，AST/ALT 比值不能预测高危或低危 PCa 的发病。
AST/ALT 比值是预测 PCa 发病的独立因素。当血清 AST/ALT 比值升高时，PCa 的发病风险显著增加，有助于 PCa 的临床诊断。我们仍需要进行多中心研究来验证 AST/ALT 比值在 PCa 发展中的作用。
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