HIV 患者出现逆转录病毒反弹综合征相关性脑膜炎时脑脊液中腺苷脱氨酶升高：1 例报告。

Elevation of CSF adenosine deaminase in HIV patient with meningitis from retroviral rebound syndrome, a case report.

机构信息

Department of Infectious Diseases, Kobe City Medical Center General Hospital, Japan; Department of General Internal Medicine, Kobe City Medical Center General Hospital, Japan.

出版信息

Int J Infect Dis. 2020 Sep;98:297-298. doi: 10.1016/j.ijid.2020.06.050. Epub 2020 Jun 17.

DOI:10.1016/j.ijid.2020.06.050

PMID:32562847

Abstract

Adenosine deaminase (ADA) in cerebrospinal fluid (CSF) is considered to be a useful biomarker in differentiating tuberculous meningitis (TBM) from other meningitis in non-HIV patients. However, its specificity decreases in patients with HIV, and other diseases such as cytomegalovirus encephalitis, toxoplasmosis or meningeal lymphomatosis can also elevate ADA in CSF. We here report a rare case of retroviral rebound syndrome in a HIV patient, whose ADA in CSF was elevated.

摘要

脑脊液中的腺苷脱氨酶（ADA）被认为是鉴别非 HIV 患者结核性脑膜炎（TBM）与其他脑膜炎的有用生物标志物。然而，在 HIV 患者中其特异性降低，其他疾病如巨细胞病毒性脑炎、弓形虫病或脑膜淋巴瘤也可使 CSF 中的 ADA 升高。我们在此报告一例 HIV 患者罕见的逆转录病毒反弹综合征病例，其脑脊液中的 ADA 升高。