National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, People's Republic of China; Chinese Center for Tropical Diseases Research, Shanghai, People's Republic of China; Key Laboratory of Parasite and Vector Biology, Ministry of Health, Shanghai, People's Republic of China; National Center for International Research on Tropical Diseases, Ministry of Science and Technology, Shanghai, People's Republic of China; WHO Collaborating Centre for Tropical Diseases, Shanghai, People's Republic of China.
National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, People's Republic of China; Chinese Center for Tropical Diseases Research, Shanghai, People's Republic of China; Key Laboratory of Parasite and Vector Biology, Ministry of Health, Shanghai, People's Republic of China; National Center for International Research on Tropical Diseases, Ministry of Science and Technology, Shanghai, People's Republic of China; WHO Collaborating Centre for Tropical Diseases, Shanghai, People's Republic of China.
Adv Parasitol. 2020;110:245-267. doi: 10.1016/bs.apar.2020.04.004. Epub 2020 May 18.
Clonorchiasis is caused by ingestion of raw freshwater fish containing infective larvae of Clonorchis sinensis. China harbours the largest number of people with C. sinensis infection. During the past three decades, the National Institute of Parasitic Diseases, affiliated to the Chinese Center for Disease Control and Prevention (NIPD) conducted many studies to facilitate the control on clonorchiasis. Three national surveys have shown the updated epidemiology of clonorchiasis in China. Recently, a national surveillance system has also been established, which will enable the production of high-resolution map. The evaluation of the disease burden has enhanced the awareness on clonorchiasis. Diverse diagnosis techniques including rapid screening by questionnaire, serological tests, faecal examination and a molecular method have been developed or evaluated. The NIPD also participated in the early evaluation of praziquantel against clonorchiasis, which enhanced its application in China. Also, the NIPD has verified the efficacy of tribendimidine against clonorchiasis. A new sustainable strategy is also being explored. However, more research is expected to further facilitate control of clonorchiasis in China, as well as international cooperation in fighting human liver fluke infections in Asia.
华支睾吸虫病系食用含有华支睾吸虫囊蚴的淡水鱼而感染。中国是华支睾吸虫感染人数最多的国家。过去 30 余年来，中国疾病预防控制中心寄生虫病预防控制所（简称寄生虫病所）在华支睾吸虫病防治研究方面取得了显著成绩。寄生虫病所先后进行了 3 次全国性流调，基本掌握了中国华支睾吸虫病的流行现状。近年建立了全国性的监测系统，可绘制高分辨率的流行地图。对疾病负担的评估提高了对该病的认识。已开发或评估了多种诊断技术，包括快速问卷筛查、血清学检测、粪便检查和分子方法。寄生虫病所还参与了吡喹酮早期抗华支睾吸虫病的评估，促进了其在中国的应用。此外，寄生虫病所还验证了三苯双脒治疗华支睾吸虫病的疗效。目前正在探索新的可持续策略。然而，还需要更多的研究来进一步促进中国的华支睾吸虫病防治工作，以及在亚洲开展防治肝吸虫感染的国际合作。
