Misir Abdulhamit, Yildiz Kadir Ilker, Kizkapan Turan Bilge, Incesoy Mustafa Alper
Health Sciences University, Gaziosmanpasa Taksim Training and Research Hospital, Istanbul, Turkey.
Health Sciences University, Baltalimani Bone and Joint Diseases Training and Research Hospital, Istanbul, Turkey.
Knee. 2020 Jun;27(3):633-641. doi: 10.1016/j.knee.2020.04.013. Epub 2020 Apr 30.
To compare selected morphological parameters between normal and osteoarthritic (OA) knees, as well as to evaluate differences in these parameters between Kellgren-Lawrence (K-L) grades of OA.
Knee joint morphology was evaluated using magnetic resonance (MR) images of 200 participants with knee OA (50 each of K-L grades 1-4) and 50 without knee OA, matched for age, body mass index, sex, and tibiofemoral angle. Knees with a coronal alignment within five degrees of neutral and no apparent bone loss on radiographs were included. Twenty-one morphologic parameters of the distal femur and proximal tibia were measured on MR images. Correlation between the K-L grade and measured parameters and differences in measured parameters across the K-L grades and between the OA and control groups were evaluated.
The K-L grade was significantly correlated with multiple distal femur measurements including the posterior condylar angle (PCA), lateral epicondyle to posterior condylar cartilage (LEPC) length, medial epicondyle to posterior condylar cartilage (MEPC) length, medial epicondyle to distal cartilage (MEDC) length, medial tibial slope angle, femoral condylar cartilage height difference (FCHDc), and femoral condylar bone height difference (FCHDb) (P < 0.05). A significant difference was identified between the different K-L grades with regard to PCA, LEPC, MEPC, MEDC, and FCHDc (P < 0.05). There was no correlation between K-L grade and measured proximal tibial parameters.
Among knees without significant angular deformity, progression of knee OA is associated with a change in the morphology of the femoral condyles but not of the proximal tibia.
比较正常膝关节与骨关节炎（OA）膝关节的特定形态学参数，并评估这些参数在骨关节炎Kellgren-Lawrence（K-L）分级之间的差异。
使用磁共振（MR）图像评估200例膝关节骨关节炎患者（K-L分级1-4级各50例）和50例无膝关节骨关节炎患者的膝关节形态，这些患者在年龄、体重指数、性别和胫股角方面相匹配。纳入冠状位对线在中立位5度以内且X线片上无明显骨质流失的膝关节。在MR图像上测量股骨远端和胫骨近端的21个形态学参数。评估K-L分级与测量参数之间的相关性，以及K-L分级之间和OA组与对照组测量参数的差异。
K-L分级与多个股骨远端测量值显著相关，包括后髁角（PCA）、外侧髁上嵴至后髁软骨（LEPC）长度、内侧髁上嵴至后髁软骨（MEPC）长度、内侧髁上嵴至远端软骨（MEDC）长度、胫骨内侧坡度角、股骨髁软骨高度差（FCHDc）和股骨髁骨高度差（FCHDb）（P<0.05）。在PCA、LEPC、MEPC、MEDC和FCHDc方面，不同K-L分级之间存在显著差异（P<0.05）。K-L分级与测量的胫骨近端参数之间无相关性。
在无明显角度畸形的膝关节中，膝关节骨关节炎的进展与股骨髁形态的改变有关，而与胫骨近端形态无关。
