Osakidetza, Hospital Universitario Basurto, Servicio de Microbiología Clínica y Control de Infección, Avenida Montevideo 18, 48013 Bilbao, Spain.
Osakidetza, Hospital Universitario Basurto, Servicio de Microbiología Clínica y Control de Infección, Avenida Montevideo 18, 48013 Bilbao, Spain.
Enferm Infecc Microbiol Clin (Engl Ed). 2021 May;39(5):234-240. doi: 10.1016/j.eimc.2020.04.014. Epub 2020 Jun 17.
Herpes simplex virus type 2 (HSV-2) is the most common cause of genital herpes (GH), but genital infection by herpes simplex virus type 1 (HSV-1) is increasing. The aim of this study was to analyze and compare epidemiological characteristics of patients with GH.
Retrospective study conducted from January 2004 to December 2015 in patients with GH attended at two Sexually Transmitted Diseases (STDs) medical consultation of Bilbao-Basurto Integrated Health Organisation in Northern Spain. Patient's medical history was reviewed and data of interest was analyzed.
One thousand three patients (524 male and 479 female) were reviewed. HSV-2 was detected in 74%. The proportion of HSV-1 increased during the study period, significantly in men (28% in 2004-2007 vs. 50% in 2012-2015). More female than male had HSV-1 infection (56% vs. 44%). The proportion of primary infection was higher among HSV-1 compared to HSV-2 (79% vs. 21%). Among the patients with HSV-1, primary infection was higher among men (86%) and in younger than 30 years. Recurrent GH was higher among HSV-2 infections (63%). In a multivariate model older age, geographic origin outside Spain, recurrent infection, prior contact with a partner's genital herpetic lesions, previous N. gonorrhoeae infection and prostitution were significantly associated with HSV-2 infection.
HSV-2 was the most common causative agent of GH, but the proportion of HSV-1 increased. Overall, antecedent of STD and sexual risk behaviors were more frequent in patients with genital HSV-2 infection.
单纯疱疹病毒 2 型（HSV-2）是生殖器疱疹（GH）最常见的病因，但单纯疱疹病毒 1 型（HSV-1）引起的生殖器感染正在增加。本研究旨在分析和比较 GH 患者的流行病学特征。
对 2004 年 1 月至 2015 年 12 月期间在西班牙北部毕尔巴鄂巴斯克综合卫生组织两家性传播疾病（STD）医疗咨询中心就诊的 GH 患者进行回顾性研究。回顾患者的病史并分析相关数据。
共回顾了 1300 例患者（524 名男性和 479 名女性）。检测到 HSV-2 的比例为 74%。在研究期间，HSV-1 的比例有所增加，男性尤为明显（2004-2007 年为 28%，2012-2015 年为 50%）。女性中 HSV-1 感染的比例高于男性（56%比 44%）。与 HSV-2 相比，HSV-1 的原发性感染比例更高（79%比 21%）。在 HSV-1 患者中，原发性感染在男性（86%）和 30 岁以下人群中更为常见。HSV-2 感染患者中复发性 GH 比例更高（63%）。在多变量模型中，年龄较大、原籍非西班牙、复发性感染、曾接触过性伴侣的生殖器疱疹皮损、既往淋病奈瑟菌感染和卖淫与 HSV-2 感染显著相关。
HSV-2 是 GH 的最常见病因，但 HSV-1 的比例有所增加。总体而言，STD 病史和性行为风险因素在生殖器 HSV-2 感染患者中更为常见。
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