Zhao En, Yu Qian, Ali Abdoulaye Idriss, Mu Yulu, Shi Yachen, Zhu Lin
Department of Gastroenterology, Affiliated Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu 210009, China.
Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu 210009, China.
Gen Hosp Psychiatry. 2022 Jan-Feb;74:118-125. doi: 10.1016/j.genhosppsych.2020.06.002. Epub 2020 Jun 11.
A combination of inflammatory bowel disease (IBD) and psychological comorbidities can influence the natural course of IBD. A systematic review and meta-analysis was performed to examine whether a standard IBD medical therapy without any antipsychotic intervention has beneficial effects on depression/anxiety in IBD patients.
PubMed and Web of Science databases were systematically searched for related literature from their inception to March 2020. The random-effects model was used to calculate the standardized mean difference (SMD). A total of 16 eligible studies were included in the present meta-analysis.
Compared with baseline assessments, IBD patients with standard IBD medication had significantly reduced depression assessment scores (pooled SMD = 0.500; 95% confidence interval: 0.207, 0.793; P = 0.001). These results were obtained without any psychological interventions. Additionally, no significant differences in anxiety-related scores were detected between the baseline assessments and the end of therapy assessments (pooled SMD = 0.083; 95% confidence interval: -0.120, 0.285; P = 0.425). The meta-regression and subgroup analyses revealed that differences in assessment tools and medications might be the main source of heterogeneity.
Standard IBD treatments can significantly alleviate the depressive symptoms in IBD patients. However, more studies are needed to analyze this association.
炎症性肠病（IBD）与心理共病相结合会影响IBD的自然病程。进行了一项系统评价和荟萃分析，以检验在没有任何抗精神病药物干预的情况下，标准的IBD药物治疗对IBD患者的抑郁/焦虑是否有有益影响。
系统检索PubMed和Web of Science数据库，从建库至2020年3月的相关文献。采用随机效应模型计算标准化均数差（SMD）。本荟萃分析共纳入16项符合条件的研究。
与基线评估相比，接受标准IBD药物治疗的IBD患者抑郁评估得分显著降低（合并SMD = 0.500；95%置信区间：0.207，0.793；P = 0.001）。这些结果是在没有任何心理干预的情况下获得的。此外，在基线评估和治疗结束评估之间，未检测到焦虑相关得分有显著差异（合并SMD = 0.083；95%置信区间：-0.120，0.285；P = 0.425）。荟萃回归和亚组分析表明，评估工具和药物的差异可能是异质性的主要来源。
标准的IBD治疗可显著减轻IBD患者的抑郁症状。然而，需要更多研究来分析这种关联。
