Scheftner W A, Young M A, Endicott J, Coryell W, Fogg L, Clark D C, Fawcett J
Rush-Presbyterian - St Luke's Medical Center.
Br J Psychiatry. 1988 Dec;153:805-9. doi: 10.1192/bjp.153.6.805.
Family history was examined to determine whether suicide in index patients is associated with suicidal behaviour or mental disorder in their first-degree relatives. Twenty-seven suicides occurred within 5 1/2 years among 955 affectively disordered probands. Among 5042 proband relatives aged 18 years and older, 44 had committed suicide prior to proband entry to the study; however, only one was the relative of a proband suicide. Only two of the relatives who committed suicide were themselves related. As to attempted suicide of relatives, neither the number of attempts nor the severity of attempt was predictive of suicide in probands. Comparison of diagnosis between groups of relatives showed more drug abuse among relatives of proband suicides; this appears to be related to drug abuse among the proband suicides themselves. In contrast to the clustering of suicides within biological families found in other research, these data do not support the use of family history as a clinically useful indicator of suicidal potential in affectively disordered probands.
研究家族病史以确定索引患者的自杀行为是否与其一级亲属的自杀行为或精神障碍有关。在955名情感障碍先证者中，5年半内发生了27起自杀事件。在5042名18岁及以上的先证者亲属中，44人在其先证者进入研究之前自杀；然而，只有一人是先证者自杀者的亲属。自杀的亲属中只有两人有亲属关系。关于亲属的自杀未遂情况，未遂次数和未遂严重程度均不能预测先证者的自杀行为。对亲属组之间的诊断比较显示，先证者自杀者的亲属中药物滥用情况更多；这似乎与先证者自杀者自身的药物滥用有关。与其他研究中发现的生物家族内自杀聚集现象不同，这些数据不支持将家族病史作为情感障碍先证者自杀可能性的临床有用指标。
