Jaworek Andrzej Kazimierz, Jaworek Magdalena, Szafraniec Krystyna, Pawlicka Aleksandra, Wojas-Pelc Anna
Jagiellonian University Medical College, Kraków, Poland: Department of Dermatology.
Jagiellonian University Medical College, Kraków, Poland: Institute of Physiotherapy, Faculty of Health Sciences.
Pol Merkur Lekarski. 2020 Jun 17;48(285):162-165.
Atopic dermatitis (AD - atopic eczema) is a chronic inflammatory dermatosis resulting from complex genetic, epigenetic and environmental interactions with an overlapping defect in the epidermal barrier.AD is one of the most common inflammatory dermatoses in children and adults.
The aim of the study was to assess the relationship between serum basal tryptase (sBT) and total IgE (tIgE) level in blood serum and the severity of lesions (SCORAD; SCORing atopic dermatitis).
The study was performed in the group of adult patients (57 people, F/M: 30/27; average age: 37.5 years) and in the control group (10 people, K/M: 6/4; average age: 44 years). Diagnosis of atopic dermatitis was established by a dermatologist-allergist specialist based on the criteria of Hanifin and Rajka. The severity of lesions was determined on the SCORAD scale (SCORing atopic dermatitis).
The distribution of tryptase concentration did not differ statistically significantly between patients with various disease severity and the control group also the severity of skin lesions was significantly higher (p<0.001) in patients whose tIgE level exceeded 3500 IU / ml. Conclusion. sBT did not prove to be a useful biomarker in assessing.
sBT did not prove to be a useful biomarker in assessing severity of AD. The present study demonstrated that in the patients with atopic dermatitis the concentration of total IgE was correlated with severity of the disease symptoms.
特应性皮炎（AD - 特应性湿疹）是一种慢性炎症性皮肤病，由复杂的遗传、表观遗传和环境相互作用以及表皮屏障重叠缺陷导致。AD是儿童和成人中最常见的炎症性皮肤病之一。
本研究旨在评估血清基础类胰蛋白酶（sBT）和血清总IgE（tIgE）水平与皮损严重程度（SCORAD；特应性皮炎评分）之间的关系。
本研究在成年患者组（57人，女/男：30/27；平均年龄：37.5岁）和对照组（10人，女/男：6/4；平均年龄：44岁）中进行。特应性皮炎的诊断由皮肤科过敏专科医生根据Hanifin和Rajka标准确定。皮损严重程度通过SCORAD量表（特应性皮炎评分）确定。
不同疾病严重程度的患者与对照组之间类胰蛋白酶浓度分布在统计学上无显著差异，tIgE水平超过3500 IU/ml的患者皮肤损害严重程度也显著更高（p<0.001）。结论。sBT在评估中未被证明是一种有用的生物标志物。
sBT在评估AD严重程度方面未被证明是一种有用的生物标志物。本研究表明，特应性皮炎患者中总IgE浓度与疾病症状严重程度相关。
