Xu X H, Yang J, Wang L J, Yin P, Liu J M, Dong W L, Wang W, Wang X, Qin L, Zhou M G
Division of Comprehensive Prevention and Evaluation, National Center for Chronic and Non-communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Division of Science, Education and International Cooperation, National Center for Chronic and Non-communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2020 Jun 10;41(6):839-844. doi: 10.3760/cma.j.cn112338-20191205-00861.
To quantitatively analyze the death and disability-adjusted life years (DALY) attributed to high level serum LDL-C in Chinese population in 2017. Data were obtained from the '2017 Global Burden of Disease Study (GBD2017)'. Population attributable fraction (PAF), number and rate of deaths and DALY attributable to high LDL-C were used to describe the burden of disease by gender, age groups, diseases and provinces in China. Both rates on mortality and DALY were standardized by GBD world population. In 2017, 862 759 deaths were caused by high level serum LDL-C in China, that accounting for 8.25 of the total deaths. Of the attributable deaths, 705 355 (81.76) persons died from ischemic heart disease (IHD), while the remaining 18.24 from ischemic stroke (IS). High LDL-C accounted for 40.30 of the total deaths from ischemic heart disease and 18.49 from ischemic stroke. The highest PAF of death (13.70) appeared in Jilin province and the lowest in Zhejiang province (4.65). PAF of death was seen higher in females than in males, while both age-standardized rates of mortality and DALY appeared higher in males than in females. High LDL-C attributed mortality rate appeared as 61.08/100 000 after standardization in Chinese population. High LDL-C attributed DALYs were 18.16 million person years, among which 76.76 were caused by IHD (13.94 million person years), with DALY rate as 1285.83/100 000. Among provinces, Heilongjiang showed the highest standardized DALY rate, and Zhejiang the lowest. The PAF, number of deaths, rates on mortality and DALY caused by high LDL-C were high among residents above 70 years old, with the DALY number as 8.56 million person years, highest seen in the age group from 50 to 69 years old. The burden of disease attributed to high level LDL-C was quite high and with gender, age group and interprovincial differences, in China in 2017.
定量分析2017年中国人群中高水平血清低密度脂蛋白胆固醇（LDL-C）所致的死亡及伤残调整生命年（DALY）。数据来自“2017年全球疾病负担研究（GBD2017）”。采用人群归因分数（PAF）、归因于高LDL-C的死亡人数及死亡率、DALY来描述中国不同性别、年龄组、疾病及省份的疾病负担。死亡率和DALY率均采用GBD世界人口进行标准化。2017年，中国高水平血清LDL-C导致862759例死亡，占总死亡人数的8.25%。在这些归因死亡中，705355例（81.76%）死于缺血性心脏病（IHD），其余18.24%死于缺血性卒中（IS）。高LDL-C导致的死亡占缺血性心脏病总死亡人数的40.30%，占缺血性卒中总死亡人数的18.49%。死亡PAF最高的是吉林省（13.70%），最低的是浙江省（4.65%）。女性的死亡PAF高于男性，而年龄标准化死亡率和DALY率男性均高于女性。中国人群经标准化后高LDL-C归因死亡率为61.08/10万。高LDL-C归因DALY为1816万人年，其中76.76%由IHD导致（1394万人年），DALY率为1285.83/10万。在各省中，黑龙江省的标准化DALY率最高，浙江省最低。70岁以上人群中，高LDL-C导致的PAF、死亡人数、死亡率和DALY均较高，DALY数为856万人年，50至69岁年龄组最高。2017年中国高水平LDL-C所致疾病负担相当高，且存在性别、年龄组及省际差异。
