National Medical Research Center for Children's Health, Lomonosovskiy av., 2a, Moscow, Russia.
National Medical Research Center for Children's Health, Lomonosovskiy av., 2a, Moscow, Russia.
Vaccine. 2020 Jul 14;38(33):5114-5118. doi: 10.1016/j.vaccine.2020.05.075. Epub 2020 Jun 18.
Streptococcus pneumoniae is a highly recombinogenic pathogen. The ability of pneumococci to acquire and incorporate exogenous DNA is an important evolutionary mechanism for adaptation to clinical interventions such as antibiotic therapy and vaccination. Herein, using whole genome sequencing we detected a multiple drug-resistant serotype 15A pneumococcus emerged by capsular switching from serotype 19A/ST276. The dissemination of recombinant multiple drug-resistant pneumococcal clones with non-vaccine type capsule is of concern and warrants thorough monitoring of serotype and genotype structure within pneumococcal populations.
肺炎链球菌是一种高度重组的病原体。肺炎球菌获取和整合外源 DNA 的能力是其适应临床干预（如抗生素治疗和疫苗接种）的重要进化机制。在此，我们通过全基因组测序检测到了一株由 19A/ST276 血清型荚膜转换而来的、具有多重耐药性的 15A 血清型肺炎球菌，该菌对多种药物耐药。具有非疫苗型荚膜的重组多重耐药肺炎球菌克隆的传播令人担忧，需要对肺炎球菌群体中的血清型和基因型结构进行全面监测。
