Rutakingirwa Morris K, Kiiza Tadeo K, Rhein Joshua
Infectious Diseases Institute, Makerere University, P.O. Box 22418, Kampala, Uganda.
University of Minnesota, Minneapolis, MN, 55455, USA.
Med Mycol Case Rep. 2020 Jun 11;29:29-31. doi: 10.1016/j.mmcr.2020.06.003. eCollection 2020 Sep.
There is an increasing recognition of patients presenting with cryptococcal meningitis despite having a negative CSF cryptococcal antigen (CrAg). In this report, we describe three cases of patients with advanced immunosuppression who presented to hospital with "false negative" CSF cryptococcal antigen, two of whom had a positive fungal culture. We describe the challenge of CSF-CrAg negative cryptococcal meningitis and explore ways to overcome this challenge using newer diagnostic techniques.
尽管脑脊液隐球菌抗原（CrAg）检测呈阴性，但越来越多的隐球菌性脑膜炎患者被识别出来。在本报告中，我们描述了三例免疫抑制严重的患者，他们因脑脊液隐球菌抗原“假阴性”而入院，其中两例真菌培养呈阳性。我们描述了脑脊液CrAg阴性的隐球菌性脑膜炎所面临的挑战，并探讨了使用更新的诊断技术来克服这一挑战的方法。
