Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health (BIH), Berlin, Germany.
Berlin Institute of Health, BIH, Berlin, Germany.
Eur J Cancer Care (Engl). 2020 Sep;29(5):e13279. doi: 10.1111/ecc.13279. Epub 2020 Jun 21.
As adolescent cancer patients may suffer from infertility following treatment, fertility counselling is essential. Our aim was to explore the current situation in four European countries in terms of (I) education about the risk for infertility, (II) counselling on fertility preservation, (III) patients' knowledge on fertility, (IV) sufficiency of information and (V) uptake of cryopreservation.
In total, 113 patients (13-20 years) at 11 study centres completed a self-report questionnaire three and six months after cancer diagnosis. Multivariate logistic regression was used to estimate odds ratios (OR) with 95% confidence intervals (CI).
As many as 80.2% of participants reported having received education about the risk for infertility prior to treatment, 73.2% recalled counselling on fertility preservation. Only 52.3% stated they felt sufficiently informed to make a decision. Inability to recall counselling on fertility preservation (OR = 0.03, CI: 0.00-0.47) and female gender (OR = 0.11, CI: 0.03-0.48) was associated with lower use of cryopreservation, whereas older age was associated with higher use.
Fertility counselling was available to a relatively high proportion of patients, and it did influence the utilisation of cryopreservation. However, many patients did not feel sufficiently informed. Further improvement is needed to enable adolescent cancer patients to make an informed decision on fertility preservation.
由于青少年癌症患者在治疗后可能会面临不孕不育的风险，因此进行生育咨询至关重要。我们的目的是探讨四个欧洲国家在以下方面的现状：（I）关于不孕风险的教育，（II）生育力保留咨询，（III）患者对生育力的了解，（IV）信息的充分性，以及（V）冷冻保存的接受情况。
共有 113 名（13-20 岁）在 11 个研究中心的患者在癌症诊断后三个月和六个月时完成了一份自我报告问卷。采用多变量逻辑回归估计比值比（OR）及其 95%置信区间（CI）。
多达 80.2%的参与者报告在治疗前接受了关于不孕风险的教育，73.2%的参与者回忆接受了生育力保留咨询。只有 52.3%的人表示他们感到有足够的信息做出决策。无法回忆起生育力保留咨询（OR=0.03，CI：0.00-0.47）和女性性别（OR=0.11，CI：0.03-0.48）与冷冻保存的使用较低相关，而年龄较大则与较高的使用相关。
生育咨询在相对较高比例的患者中可用，并且确实影响了冷冻保存的使用。然而，许多患者没有感到有足够的信息。需要进一步改进，以使青少年癌症患者能够就生育力保留做出知情决策。
