Yan Minchao, Li Yuan, Zeng Hui, Zhao Xiaoyan, Wu Haibing, Qian Wenbin, Guo Xiaojun
Department of Hematology, First Affiliated Hospital of Jiaxing University, Jiaxing, People's Republic of China.
Malignant Lymphoma Diagnosis and Therapy Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People's Republic of China.
Hematology. 2020 Dec;25(1):264-269. doi: 10.1080/16078454.2020.1784615.
Peripheral neuropathy can induce marked disability and negative effects on quality of life and is the most common therapy-related complication in multiple myeloma patients treated with bortezomib. Currently, there is no useful method to prevent or treat it. So, it is necessary to study the clinical efficacy of rat nerve growth factor combined with vitamin B for the treatment of peripheral neuropathy in multiple myeloma patients. Sixty multiple myeloma patients who developed peripheral neuropathy after bortezomib-based chemotherapy in Jiaxing First Hospital from October 2015 to May 2018 were randomly divided into treatment and control groups. Changes in serum NGF level and electromyograms before and after treatment were analyzed, and the effects were evaluated via a FACT/GOG-Ntx questionnaire score. After treatment, the NGF level in the treatment group (13.2 ± 3.73 pg/ml) was higher than that in the control group (9.22 ± 2.93 pg/ml, < 0.05). Improvements in the electromyograms were more pronounced in treatment group than those in the control group, with statistical significance. The FACT/GOG-Ntx questionnaire scores, both in the treatment group and the control group, were decreased (4.00 ± 1.58 vs. 5.20 ± 2.33; < 0.05), and the alleviation of the symptoms in the treatment group were more obvious. Rat nerve growth factor combined with vitamin B is a safe and effective method for treating peripheral neuropathy in multiple myeloma patients.
周围神经病变可导致明显的残疾，并对生活质量产生负面影响，是接受硼替佐米治疗的多发性骨髓瘤患者中最常见的治疗相关并发症。目前，尚无有效的预防或治疗方法。因此，有必要研究大鼠神经生长因子联合维生素B治疗多发性骨髓瘤患者周围神经病变的临床疗效。选取2015年10月至2018年5月在嘉兴市第一医院接受基于硼替佐米化疗后出现周围神经病变的60例多发性骨髓瘤患者，随机分为治疗组和对照组。分析治疗前后血清神经生长因子（NGF）水平及肌电图的变化，并通过FACT/GOG-Ntx问卷评分评估疗效。治疗后，治疗组的NGF水平（13.2±3.73 pg/ml）高于对照组（9.22±2.93 pg/ml，P<0.05）。治疗组肌电图改善情况比对照组更明显，差异有统计学意义。治疗组和对照组的FACT/GOG-Ntx问卷评分均降低（4.00±1.58 vs. 5.20±2.33；P<0.05），且治疗组症状缓解更明显。大鼠神经生长因子联合维生素B是治疗多发性骨髓瘤患者周围神经病变的一种安全有效的方法。
