Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Department of Hepatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Aging (Albany NY). 2020 Jun 21;12(12):11878-11892. doi: 10.18632/aging.103360.
Primary hepatocellular carcinoma (PHCC) has a poor prognosis and high short-term mortality rate, even after resection. Thus, early diagnosis in PHCC cases can help improve quality of life via personalized management strategies.
The risk score system (RSS) were classified as low risk (<5 points), medium risk (5-10 points), or high risk (>10 points). The areas under the receiver operating characteristic curves were 0.80 in the training cohort and 0.69 in the validation cohort, which indicated satisfactory prognostic performance. The Hosmer-Lemeshow goodness of fit test (>0.05) revealed consistent performance in both groups. The concordance index (C-index: 0.663, 95% CI: 0.618-0.708) revealed excellent discrimination and good calibration in the validation cohort.
This simple RSS, which is based on clinical and laboratory data from patients undergoing resection of PHCC, might allow clinicians and medical staff to better manage PHCC.
A total of 672 PHCC cases were retrospectively obtained from the First Affiliated Hospital of Wenzhou Medical University between January 2007 and February 2015. Cox proportional hazard models were used to identify independent predictors of mortality. Kaplan-Meier curves and the log-rank test were used to examine the relationships between the prognostic factors and overall mortality.
原发性肝细胞癌（PHCC）预后差，短期死亡率高，即使在切除后也是如此。因此，PHCC 病例的早期诊断可以通过个性化管理策略来提高生活质量。
风险评分系统（RSS）分为低危（<5 分）、中危（5-10 分）或高危（>10 分）。训练队列的受试者工作特征曲线下面积为 0.80，验证队列为 0.69，表明预后表现良好。Hosmer-Lemeshow 拟合优度检验（>0.05）表明两组均具有一致的性能。一致性指数（C 指数：0.663，95%CI：0.618-0.708）在验证队列中显示出良好的区分度和校准度。
该 RSS 基于接受 PHCC 切除术的患者的临床和实验室数据，可能使临床医生和医务人员能够更好地管理 PHCC。
回顾性收集 2007 年 1 月至 2015 年 2 月温州医科大学第一附属医院 672 例 PHCC 病例。Cox 比例风险模型用于确定死亡率的独立预测因素。Kaplan-Meier 曲线和对数秩检验用于检验预后因素与总死亡率之间的关系。
