Winer J B, Hughes R A
Department of Neurology, Guy's Hospital, United Medical School, London.
Q J Med. 1988 Sep;68(257):735-9.
The frequency of autonomic dysfunction and significant arrhythmia was investigated in a series of 100 patients who presented with an acute idiopathic neuropathy considered to be due to Guillain-Barré syndrome. Eleven of 33 patients requiring ventilation developed serious cardiac rhythm disturbances and seven of these patients died. Approximately 25 per cent of patients had a sinus tachycardia or raised systolic blood pressure and half had reduced sinus arrhythmia indicated by an abnormally low R-R interval variation on deep breathing. Systolic hypertension and reduced R-R interval variation were significantly more common in patients who subsequently developed serious arrhythmias than those who did not. Only those patients that required ventilation developed serious arrhythmias and these were often preceded by wide fluctuations of pulse or blood pressure and transient asystole following tracheal suction.
在一系列100例表现为急性特发性神经病（被认为由吉兰 - 巴雷综合征所致）的患者中，对自主神经功能障碍和显著心律失常的发生率进行了调查。33例需要通气的患者中有11例出现严重的心律紊乱，其中7例患者死亡。约25%的患者有窦性心动过速或收缩压升高，半数患者深呼吸时R-R间期变异异常降低，提示窦性心律失常减少。随后发生严重心律失常的患者中，收缩期高血压和R-R间期变异减少比未发生严重心律失常的患者更为常见。只有那些需要通气的患者出现了严重心律失常，且这些心律失常之前常有脉搏或血压的大幅波动以及气管吸引后的短暂心脏停搏。
