Huntsman Cancer Institute, Salt Lake City, UT 84112, USA.
Department of General, Visceral, and Transplantation Surgery, Heidelberg University Hospital, Heidelberg 69120, Germany.
Appl Physiol Nutr Metab. 2020 Nov;45(11):1306-1309. doi: 10.1139/apnm-2019-0836. Epub 2020 Jun 22.
To determine associations between physical activity (PA), sedentary behavior (SB), and oxidative stress in colorectal cancer patients, ColoCare Study participants in Germany wore an accelerometer 6 and/or 12 months after surgery. Spearman partial correlations were used to assess associations between PA and urinary concentrations of oxidized guanine, a validated marker of oxidative stress. There were no significant associations between PA or SB and oxidized guanine in = 76 measurements (ng/mg creatinine; = 0.03, = 0.76 for PA, = -0.05, = 0.69 for SB). Objectively measured PA was not associated with a marker of oxidative stress in colorectal cancer patients.
为了确定体力活动（PA）、久坐行为（SB）与结直肠癌患者氧化应激之间的关联，德国 ColoCare 研究的参与者在手术后 6 个月和/或 12 个月佩戴了加速度计。采用斯皮尔曼偏相关分析评估 PA 与尿中氧化鸟嘌呤浓度之间的相关性，氧化鸟嘌呤是氧化应激的一个经过验证的标志物。在 76 次测量中（ng/mg 肌酐），PA 或 SB 与氧化鸟嘌呤之间没有显著关联（PA： = 0.03， = 0.76；SB： = -0.05， = 0.69）。在结直肠癌患者中，客观测量的 PA 与氧化应激标志物无关。
