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Evolution of clonal dynamics and differential response to targeted therapy in a case of systemic mastocytosis with associated myelodysplastic syndrome.

作者信息

Yun Hyun Don, Antony Marie Lue, Linden Michael A, Noble-Orcutt Klara E, Eckfeldt Craig E, Ustun Celalettin, Nelson Andrew C, Sachs Zohar

机构信息

Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN, United States; Division of Hematology, Oncology and Cell Therapy, Department of Medicine, Rush University, Chicago, IL, United States.

Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN, United States.

出版信息

Leuk Res. 2020 Aug;95:106404. doi: 10.1016/j.leukres.2020.106404. Epub 2020 Jun 11.

Abstract
摘要

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本文引用的文献

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Mastocytosis: 2016 updated WHO classification and novel emerging treatment concepts.
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Mass cytometry analysis reveals hyperactive NF Kappa B signaling in myelofibrosis and secondary acute myeloid leukemia.
Leukemia. 2017 Sep;31(9):1962-1974. doi: 10.1038/leu.2016.377. Epub 2016 Dec 23.
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Advanced systemic mastocytosis: from molecular and genetic progress to clinical practice.
Haematologica. 2016 Oct;101(10):1133-1143. doi: 10.3324/haematol.2016.146563.
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Stat5 is critical for the development and maintenance of myeloproliferative neoplasm initiated by Nf1 deficiency.
Haematologica. 2016 Oct;101(10):1190-1199. doi: 10.3324/haematol.2015.136002. Epub 2016 Jul 14.
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Efficacy and Safety of Midostaurin in Advanced Systemic Mastocytosis.
N Engl J Med. 2016 Jun 30;374(26):2530-41. doi: 10.1056/NEJMoa1513098.
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TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients.
Blood. 2014 Oct 23;124(17):2705-12. doi: 10.1182/blood-2014-06-582809. Epub 2014 Sep 15.
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STAT transcription factors in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention.
Leukemia. 2014 Feb;28(2):248-57. doi: 10.1038/leu.2013.192. Epub 2013 Jun 25.

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