INRAE, RIVERLY, 5 Avenue de la Doua, CS20244, 69625 Villeurbanne Cedex, France.
UMR-I 02 SEBIO, Models for Ecotoxicology and Toxicology Unit (METO), INERIS, 60550 Verneuil en Halatte, France.
Aquat Toxicol. 2020 Aug;225:105545. doi: 10.1016/j.aquatox.2020.105545. Epub 2020 Jun 12.
Salmonids are poikilotherms, which means that their internal temperature varies with that of water. Water temperature thus controls many of their lifecycle processes and physiological functions, which could influence the mechanisms of absorption, distribution, metabolism and excretion (ADME) of many substances, including perfluorinated alkyl acids (PFAAs). However, the processes governing the fate of PFAAs are still poorly understood in fish. Here we developed a physiologically-based toxicokinetic (PBTK) model for rainbow trout (Oncorhynchus mykiss) to study changes in physiological functions and PFAA ADME at different temperatures. The model was calibrated using experimental data from dietary exposure to perfluorooctane sulfonate at 7 °C and 19 °C. Predictions of PFOS concentrations were globally satisfactory at both temperatures, when accounting for the influence of temperature on growth, ventilation rate, cardiac output, clearances, and absorption rates. Accounting for the influence of temperature on tissue-plasma partition coefficients significantly improved predicted in-organ PFOS concentrations.
鲑鱼是变温动物，这意味着它们的内部温度随水温变化而变化。因此，水温控制着它们生命周期的许多过程和生理功能，这可能会影响包括全氟烷基酸（PFAAs）在内的许多物质的吸收、分布、代谢和排泄（ADME）机制。然而，鱼类中 PFAAs 的归宿过程仍知之甚少。在这里，我们为虹鳟（Oncorhynchus mykiss）开发了一种基于生理学的毒代动力学（PBTK）模型，以研究不同温度下生理功能和 PFAA ADME 的变化。该模型使用 7°C 和 19°C 时通过饮食接触全氟辛烷磺酸的实验数据进行了校准。在考虑温度对生长、通气率、心输出量、清除率和吸收率的影响时，该模型在这两个温度下对 PFOS 浓度的预测总体上是令人满意的。考虑到温度对组织-血浆分配系数的影响，显著提高了预测的器官内 PFOS 浓度。
