Bolk Kody G, Roth Kelly A, Sharma Arun, Crosby Dana L
Southern Illinois University School of Medicine, Springfield, Illinois.
Department of Otolaryngology - Head and Neck Surgery, Southern Illinois University School of Medicine, Springfield, Illinois.
Am J Rhinol Allergy. 2020 Nov;34(6):822-829. doi: 10.1177/1945892420930967. Epub 2020 Jun 22.
Sinonasal and skull base malignancies can cause significant adverse effects on functional status and survival.
The goal of this study was to systematically review the published literature of patient-reported outcomes pertaining to treatment of sinonasal and skull base malignancy.
A systematic literature search of Medline was conducted with PubMed to identify studies that assessed patient-reported outcomes in patients with sinonasal or skull base malignancy. Patient-reported outcomes studies with at least 10 patients published in English from January 2000 to April 2017 were included. Criteria from International Society for Quality of Life guidelines and criteria unique to sinonasal and skull base malignancies were used to calculate a composite score for each article. Studies with the top 33% of scores were categorized as high quality articles.
Twenty-two articles met inclusion/exclusion criteria. Three studies (14%) reported a priori hypothesis. Eleven (50%) assessed specific quality of life domains and 10 studies (45%) performed statistical analysis on these domains. Specific symptoms were assessed in up to 32% of studies. Eight studies were characterized as high quality; these studies had higher sample sizes and more often assessed patient-reported outcomes prior to treatment compared to low quality studies.
The goal of the current study was to evaluate the quality of the current patient-reported outcomes literature on sinonasal and skull base malignancies. Areas of improvement for future studies include analysis of individual domains and disease-specific symptoms, reporting a priori hypotheses, and collecting preoperative and longitudinal patient-reported outcomes data.
鼻窦和颅底恶性肿瘤可对功能状态和生存率产生重大不利影响。
本研究的目的是系统回顾已发表的关于鼻窦和颅底恶性肿瘤治疗的患者报告结局的文献。
使用PubMed对Medline进行系统文献检索，以识别评估鼻窦或颅底恶性肿瘤患者报告结局的研究。纳入2000年1月至2017年4月以英文发表的至少有10名患者的患者报告结局研究。采用国际生活质量协会指南的标准以及鼻窦和颅底恶性肿瘤特有的标准来计算每篇文章的综合评分。得分在前33%的研究被归类为高质量文章。
22篇文章符合纳入/排除标准。三项研究（14%）报告了先验假设。11项研究（50%）评估了特定的生活质量领域，10项研究（45%）对这些领域进行了统计分析。高达32%的研究评估了特定症状。八项研究被认定为高质量；与低质量研究相比，这些研究样本量更大，且更常在治疗前评估患者报告结局。
本研究的目的是评估当前关于鼻窦和颅底恶性肿瘤的患者报告结局文献的质量。未来研究的改进方向包括对各个领域和疾病特异性症状的分析、报告先验假设以及收集术前和纵向的患者报告结局数据。
