Oskretkov V I, Gankov V A, Andreasyan A R, Klimova G I, Ovsepyan M A
Altai State Medical University of the Ministry of Health of Russia, Barnaul, Russia.
Khirurgiia (Mosk). 2020(6):38-43. doi: 10.17116/hirurgia202006138.
To find out significance of the main locking mechanisms of lower esophageal sphincter in the relapse of GERD in patients with axial hiatal hernia after previous antireflux laparoscopic surgery.
There were 103 patients with GERD and axial hiatal hernia who underwent original circular laparoscopic esophagofundoplication with correction of hiatal opening dimensions by crural and hiatal repair. Depending on generalized DeMeester index (within the normal range or its excess), all patients were divided into two groups - without relapse (group 1, =88) and with recurrent GERD (group 2, =15). Both groups were comparable by the main characteristics and postoperative follow-up period (mean - 6 years). Antireflux function was investigated by X-ray examination and endoscopy, manometry of the esophageal-gastric passage, intra-esophageal 24-hour pH-monitoring. Processing and graphical presentation of data was carried out using Statistica v.10.0 Rus software (StatSoft, USA) and Microsoft Office Excel 2013 (USA).
Abnormal gastroesophageal reflux was detected in 14.56±3.48% of patients after laparoscopic anti-reflux surgery. Recurrent hiatal hernia occurred in 20±10.33% of these patients, malfunction of lower esophageal sphincter - in 80±10.33%. Failure of cardia was caused by shortening of its length by 30.43% and decrease of tone by 6.78% with significantly (61.09%) increased tone of the stomach. Failure of cardia was manifested by increase of generalized DeMeester index in the lower third of the esophagus by 3.2 times, acidic gastroesophageal refluxes, reflux index and index reflux values. Preserved esophageal motility combined with shortening of time of esophageal clearance in patient's lying position was associated with reduced incidence of reflux-esophagitis by 77.26% even in case of recurrent GERD.
Abnormal reflux after antireflux laparoscopic surgery due to GERD with axial hiatal hernia is caused by recurrent hiatal hernia in every fifth patient while the main reason is failure of LES cuff with increased intragastric pressure.
探讨食管下括约肌主要闭锁机制在既往腹腔镜抗反流手术后有轴型食管裂孔疝的胃食管反流病(GERD)患者复发中的意义。
103例GERD合并轴型食管裂孔疝患者接受了初次腹腔镜下圆形食管胃底折叠术,并通过缝合膈肌脚和修复食管裂孔来矫正食管裂孔开口大小。根据综合DeMeester指数(在正常范围内或超出正常范围),将所有患者分为两组——无复发组(第1组,n = 88)和复发性GERD组(第2组,n = 15)。两组在主要特征和术后随访时间(平均6年)方面具有可比性。通过X线检查、内镜检查、食管-胃通道测压、食管内24小时pH监测来研究抗反流功能。使用Statistica v.10.0 Rus软件(美国StatSoft公司)和Microsoft Office Excel 2013(美国)对数据进行处理和图形展示。
腹腔镜抗反流手术后,14.56±3.48%的患者检测到异常胃食管反流。这些患者中20±10.33%出现复发性食管裂孔疝,80±10.33%存在食管下括约肌功能障碍。贲门功能衰竭是由于其长度缩短30.43%、张力降低6.78%,同时胃张力显著增加(61.09%)。贲门功能衰竭表现为食管下三分之一处的综合DeMeester指数增加3.2倍、酸性胃食管反流、反流指数和反流值指数增加。即使在复发性GERD的情况下,保留的食管动力与患者卧位时食管清除时间缩短相结合,可使反流性食管炎的发生率降低77.26%。
既往腹腔镜抗反流手术后,因GERD合并轴型食管裂孔疝导致的异常反流,每五名患者中有一名是由复发性食管裂孔疝引起的,而主要原因是LES袖带功能衰竭伴胃内压升高。