MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.
Drug Discovery Unit, University of Dundee, Dundee, UK.
Drug Discov Today. 2020 Aug;25(8):1403-1415. doi: 10.1016/j.drudis.2020.06.016. Epub 2020 Jun 20.
Advanced age is the major risk factor for multimorbidity. Current clinical practice treats the individual age-related diseases, resulting in polypharmacy. Thus, targeting the biological processes that drive ageing could prevent both multimorbidity and polypharmacy.
高龄是多种疾病的主要危险因素。目前的临床实践针对与年龄相关的个体疾病进行治疗,导致了多种药物的使用。因此,针对导致衰老的生物学过程可能既可以预防多种疾病,也可以预防多种药物的使用。