International Scientific & Technological Cooperation Base of Industrial Waste Recycling and Advanced Materials, School of Materials Science & Engineering, North Minzu University, Yinchuan 750021, China.
State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute, Sichuan University, Chengdu 610065, China.
Ultrason Sonochem. 2020 Nov;68:105217. doi: 10.1016/j.ultsonch.2020.105217. Epub 2020 Jun 9.
An amphiphilic metallo-supramolecular poly(propylene glycol)-block-poly(ethylene glycol) block copolymer containing a bis(2,2':6',2″-terpyridine) ruthenium (II) complex as a supramolecular connection between the two constituting blocks was used to prepare stable aqueous micelles which displayed a high intensity focused ultrasound (HIFU) triggered release behavior. By adjusting the HIFU time and intensity, the novel modality of HIFU triggered release allows for fine-tuning of the release kinetics of the encapsulants from the micelles in a remote and controlled way. Nuclear magnetic resonance spectroscopy, ultraviolet spectroscopy, and matrix-assisted laser desorption/ionization-time of flight mass spectrometry confirmed that the degradation of the micelles was due to the cleavage of the ether bond connected to the pyridine ring. This well controlled HIFU-copolymer micelle drug delivery system has considerable potential in targeted therapy.
一种两亲性的金属超分子聚（丙二醇）-嵌段-聚（乙二醇）嵌段共聚物，其中含有双（2,2':6',2″-三联吡啶）钌（II）配合物作为两个构成嵌段之间的超分子连接，用于制备稳定的水性胶束，其显示出高强度聚焦超声（HIFU）触发的释放行为。通过调整 HIFU 的时间和强度，可以远程和可控的方式精细调整包裹剂从胶束中释放的动力学。核磁共振波谱、紫外光谱和基质辅助激光解吸/电离-飞行时间质谱证实，胶束的降解是由于与吡啶环相连的醚键的断裂。这种良好控制的 HIFU-共聚物胶束药物递送系统在靶向治疗中具有很大的潜力。
