Grayson D R, Costa R H, Xanthopoulos K G, Darnell J E
Rockefeller University, New York, NY 10021.
Science. 1988 Feb 12;239(4841 Pt 1):786-8. doi: 10.1126/science.3257586.
Four different regulatory sites required for transcriptional stimulation by the enhancers of two unrelated liver-specific genes alpha 1-antitrypsin and transthyretin appear to bind the same nuclear protein that is found mainly in the liver. Such proteins may provide a basis for a coordinated, hepatocyte-specific control of gene transcription.
两种不相关的肝脏特异性基因α1-抗胰蛋白酶和甲状腺素运载蛋白的增强子在转录激活时所需的四个不同调控位点，似乎结合的是同一种主要在肝脏中发现的核蛋白。这类蛋白可能为基因转录的协调的、肝细胞特异性调控提供了基础。
