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继发性浆细胞白血病：一例报告

Secondary Plasma Cell Leukemia: A Case Report.

作者信息

Swaminathan Neeraja, Varadi Gabor

机构信息

Internal Medicine, Albert Einstein Medical Center, Philadelphia, USA.

Hematology and Oncology, Albert Einstein Medical Center, Philadelphia, USA.

出版信息

Cureus. 2020 Jun 19;12(6):e8693. doi: 10.7759/cureus.8693.

DOI:10.7759/cureus.8693
PMID:32577333
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7305577/
Abstract

Plasma cell leukemia (PCL) is a rare and aggressive variant of myeloma and has a poor prognosis. It needs prompt recognition in order to institute timely treatment. Given its relatively low incidence, it is an evolving area of research as well. This case report describes a patient with PCL in the setting of a previously treated myeloma. The report also reviews the clinicopathologic, cytogenetic, and immunophenotypic characteristics of PCL and its management.

摘要

浆细胞白血病（PCL）是骨髓瘤的一种罕见且侵袭性强的变异型，预后较差。需要迅速识别以便及时进行治疗。鉴于其发病率相对较低，它也是一个不断发展的研究领域。本病例报告描述了一名在既往接受过治疗的骨髓瘤背景下发生PCL的患者。该报告还回顾了PCL的临床病理、细胞遗传学和免疫表型特征及其治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e113/7305577/2238e07cb749/cureus-0012-00000008693-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e113/7305577/37591ffb0cc1/cureus-0012-00000008693-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e113/7305577/8a8ec7f8f150/cureus-0012-00000008693-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e113/7305577/7eeb891a9e13/cureus-0012-00000008693-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e113/7305577/fdd8d6db90fb/cureus-0012-00000008693-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e113/7305577/ed36a870e5f5/cureus-0012-00000008693-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e113/7305577/2238e07cb749/cureus-0012-00000008693-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e113/7305577/37591ffb0cc1/cureus-0012-00000008693-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e113/7305577/8a8ec7f8f150/cureus-0012-00000008693-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e113/7305577/7eeb891a9e13/cureus-0012-00000008693-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e113/7305577/fdd8d6db90fb/cureus-0012-00000008693-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e113/7305577/ed36a870e5f5/cureus-0012-00000008693-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e113/7305577/2238e07cb749/cureus-0012-00000008693-i06.jpg

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Plasma cell leukemia in North India: retrospective analysis of a distinct clinicohematological entity from a tertiary care center and review of literature.印度北部的浆细胞白血病：来自三级医疗中心的一种独特临床血液学实体的回顾性分析及文献综述
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CD28-mediated pro-survival signaling induces chemotherapeutic resistance in multiple myeloma.
长链非编码RNA LY86-AS1和VIM-AS1可区分浆细胞白血病患者与多发性骨髓瘤患者。
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CD28 介导的生存信号诱导多发性骨髓瘤的化疗耐药性。
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Plasma cell leukemia: consensus statement on diagnostic requirements, response criteria and treatment recommendations by the International Myeloma Working Group.浆细胞白血病：国际骨髓瘤工作组关于诊断要求、反应标准和治疗建议的共识声明。
Leukemia. 2013 Apr;27(4):780-91. doi: 10.1038/leu.2012.336. Epub 2012 Nov 21.
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How I treat plasma cell leukemia.我如何治疗浆细胞白血病。
Blood. 2012 Sep 20;120(12):2376-89. doi: 10.1182/blood-2012-05-408682. Epub 2012 Jul 26.
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