Akay Natural Ingredients Pvt. Ltd., Cochin, Kerala, India.
Leads Clinical Research and Bio Services Pvt. Ltd., Bangalore, Karnataka, India.
J Diet Suppl. 2021;18(4):387-405. doi: 10.1080/19390211.2020.1780363. Epub 2020 Jun 24.
Capsaicinoids from pungent red chilies ( and ) have received significant attention as a natural supplement for the management of obesity. However, the consumption of chili extract at physiologically relevant dosage of capsaicinoids is a challenge owing to its pungency and gastrointestinal discomforts. The present study reports the systemic absorption, safety and influence of a novel, food-grade, and sustained-release formulation of capsaicinoids-rich red chili extract using fenugreek dietary fiber (Capsifen). Twenty-four healthy overweight subjects were randomized into placebo ( = 12) and Capsifen ( = 12) groups and supplemented with 200 mg × 1/day of Capsifen (4 mg capsaicinoids/day) for 28 days. Influence of Capsifen on eating behavior and appetite was followed by Three-Factor Eating Questionnaire (TFEQ) and Council of Nutrition Appetite Questionnaire (CNAQ), respectively. Consumption of Capsifen did not reveal any adverse events or deviations in hematology and biochemical parameters related to safety. However, a significant decrease in body weight (2.1%), w/h ratio (4%) and body mass index (BMI) (2.2%) were observed among Capsifen group when compared to placebo. The TFEQ and appetite analysis revealed a significant improvement in uncontrolled eating and reduction in appetite among Capsifen subjects. The UPLC-ESI-MS/MS analysis confirmed the absorption of capsaicinoids from CAP supplementation. The study further demonstrated the safety and tolerability of Capsifen at the investigational dosage. Thus, the significant reduction in anthropometric parameters such as body weight, w/h ratio, and BMI along with the improvement in eating behaviour as well as appetite, indicated the potential body weight management effect of Capsifen.
辛辣红辣椒（和）中的辣椒素作为肥胖管理的天然补充剂受到了广泛关注。然而，由于其辛辣味和胃肠道不适，以生理相关剂量的辣椒素消耗辣椒提取物是一个挑战。本研究报告了使用葫芦巴膳食纤维（Capsifen）的新型、食品级和缓释辣椒素丰富的红辣椒提取物的全身吸收、安全性和影响。24 名健康超重受试者随机分为安慰剂（ = 12）和 Capsifen（ = 12）组，并补充 200 mg × 1/天的 Capsifen（每天 4 mg 辣椒素）28 天。通过三因素饮食问卷（TFEQ）和营养食欲咨询问卷（CNAQ）分别跟踪 Capsifen 对饮食行为和食欲的影响。Capsifen 的消费没有显示任何不良事件或与安全性相关的血液学和生化参数偏差。然而，与安慰剂相比，Capsifen 组的体重（2.1%）、w/h 比值（4%）和体重指数（BMI）（2.2%）显著下降。TFEQ 和食欲分析显示，Capsifen 组的不受控制的饮食和食欲下降有显著改善。UPLC-ESI-MS/MS 分析证实了 CAP 补充剂中辣椒素的吸收。该研究进一步证明了 Capsifen 在研究剂量下的安全性和耐受性。因此，体重、w/h 比值和 BMI 等人体测量参数的显著降低以及饮食行为和食欲的改善表明 Capsifen 具有潜在的体重管理效果。
